中药复方对肺心病肺动脉高压患者血管内皮生长因子和内皮素的影响  

Influence of Traditional Chinese Medicine Compound on VEGF and ET- 1 in Patients with Cor Pulmonale Pulmonary Hypertension

作　　者：曲妮妮[1] 刘浩[1] 马丽佳[1] 赵克明[1] 郑忻[1] 束沛[1] 兰中海 

机构地区：[1]辽宁中医药大学附属医院呼吸科,辽宁沈阳110032

出　　处：《辽宁中医杂志》2014年第3期453-455,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：辽宁省科技厅计划项目(2011225016)

摘　　要：目的:探讨研究中药复方对肺心病肺动脉高压患者血管内生长因子(VEGF)和内皮素(ET-1)的影响。方法:随机纳入240例慢性肺源性心脏病气虚血瘀兼痰阻的患者,分为观察组、对照组各120例,对照组在常规治疗的基础上联合硝苯地平口服,观察组在对照组治疗基础上予中药复方日1剂口服,疗程2周,以肺动脉压、VEGF、ET-1及VEGF、ET-1与肺动脉压相关性为观察指标。结果:经t检验统计分析显示,治疗后,肺动脉压方面,观察组较对照组改善,差异具有统计学意义(P<0.05);VEGF、ET-1方面,观察组较对照组明显改善,差异具有显著统计学意义(P<0.01)。经多元相关性显示,VEGF、ET-1与肺动脉压存在相关关系,为正相关关系。结论:中药复方可能是通过抑制VEGF、ET-1的高表达以抑制肺血管的重塑,从而降低慢性肺源性心脏病肺动脉高压,改善患者的恢复及预后,值得在临床推广研究。Objective ：To study TCM compound influence on VEGF and ET- 1 in patients with cor pulmonale pulmonary hy- pertension. Methods ：240 cases of chronic cor pulmonale patients with qi deficiency and blood stasis and phlegm obstruction were randomly divided into observation group and the control group（ n = 120）. The control group on the basis of conventional treatment combined with nifedipine orally. The observation group based on the treatment in the control group added compound Chinese med- icine, and the treatment course was 2 weeks. The pulmonary artery pressure, VEGF and ET - 1 were indicators for observing the correlation between pulmonary artery pressure. Results：After treatment, t test statistical analysis showed that pulmonary artery pressure in the observation group had statistical significance （ P 〈 0. 05 ）. VEGF and ET - 1 in the observation group were im- proved significantly than that of the control group with significant difference（P 〈0. 01 ）. The multivariate correlation showed that VEGF was positively correlated with pulmonary artery pressure and ET - 1. Conclusion： Compound Chinese medicine can be through the inhibition of VEGF and high expression of ET - 1 in order to achieve the inhibition of pulmonary vascular remodeling, reducing chronic pulmonary hypertension due to cor pulmonale and improving patient recovery and prognosis, and is worthy of popularizing in clinical research.

关 键 词：肺动脉高压 血管内皮生长因子 内皮素 

分 类 号：R541.5[医药卫生—心血管疾病]