甲钴胺联合a-硫辛酸治疗糖尿病周围神经病变的疗效观察  

Effect of Methylcobalamin and A-lipoic in Treating Diabetic Peripheral Neuropathy

作　　者：马虹[1] 高艳[1] 赵新兰[1] 

机构地区：[1]包头市蒙中医院内分泌科,内蒙古包头014040

出　　处：《中国医药指南》2014年第10期50-51,共2页Guide of China Medicine

摘　　要：目的观察甲钴胺联合a-硫辛酸治疗糖尿病周围神经病变的疗效。方法将纳入研究的DPN患者分为实验组(A组,67例)组和对照组(B组,64例)组,在控制血糖的基础上,A组给予甲钴胺+a-硫辛酸联合治疗,B组给予维生素B1、维生素B12肌内注射,3周后对两组进行评估。结果治疗3周后A组运动神经传导速度(MCV)中正中神经与腓总神经以及感觉神经传导速度(SCV)中正中神经与腓总神经均较B组及治疗前升高(P<0.05),密西根神经平分(MNCI)较前下降(P<0.05)。结论甲钴胺联合a-硫辛酸治疗糖尿病周围神经病变疗效好。Objective To investigate the effects of a-lipoic acid and Methylcobalamin in treating diabetic peripheral neuropathy （DPN）. Methods the 131 DPN patients were randomized in to the experiment group （A, n=67） and the control group （B, n=64） ,All subjects were basically treated for plasma glucose control,The A group was treated with methylcobalamin and a-lipoic acid,The B group was treated with Vitamin B1 and vitamin B12 injection after 3 week’ s treatments, the a ssessment of therapentic effect was done for evaluation Results After 3 week’s treatment,the motor nerve conduction Velocity（MCV） and sensory nerve conduction velocity（SCV）of median nerve and peroneal nerve were significantly higher in the experiment group than in the control group and than before treatment （P＆lt;0.05）.and michigam Neuropathy Screening Instrment （MNSI） Scores were significantly lower （P＆lt;0.05）. Conclusion A good trerapeutic effect is achieved in the treatment of DPN patients with methylcobalamin and a-lipoic acid.

关 键 词：糖尿病周围神经病变疗效 甲钴胺 A-硫辛酸 传导速度 

分 类 号：R587.2[医药卫生—内分泌]