马勃多糖对荷瘤模型小鼠抑瘤作用及生命延长率的影响  

Effect of Polysaccharide from Calvatia gigantea on Tumor Inhibitory and Life-prolonging Rate in Tumor Bearing Mice

作　　者：姜明华[1] 田易玲[2] 徐凌川[2] 

机构地区：[1]烟台职业学院食品与生化工程系,山东烟台264670 [2]山东中医药大学药学院,山东济南250355

出　　处：《山东中医药大学学报》2014年第2期157-158,共2页Journal of Shandong University of Traditional Chinese Medicine

摘　　要：目的:研究马勃多糖对荷瘤小鼠的抑瘤作用和生命延长率的影响。方法:采用真菌发酵法生产马勃菌丝,并提取马勃菌丝胞内多糖(CGP)。建立S-180肉瘤和抗艾氏腹水瘤(EAC)荷瘤小鼠动物模型,将所得马勃多糖进行抗S-180小鼠肉瘤和EAC的实验,观察马勃多糖抗肿瘤效果并分别计算抑瘤率和生命延长率。结果:高、中、低剂量马勃多糖对S-180荷瘤小鼠的抑瘤率分别为41.7%、36.2%、30.7%,对EAC荷瘤小鼠的生命延长率分别为38.9%、46.7%和26.4%,与阴性对照组比较有显著性差异(P<0.05,P<0.01)。结论:马勃多糖有一定的抑瘤作用,并能有效延长EAC荷瘤小鼠的生存期。Objective：To study the effect of polysaccharide from Calvatia gigantea on tumor inhibitory and life-prolonging rate of tumor bearing mice. Methods ：Submerged fermentation technology was used to produce Calvatia gigantea mycelia,and Calvatia gigantea polysaccharide（CGP） was extracted from the intercellular mycelia. Taking sarcoma S-180 and Ehrlich ascites tumor（EAC） bearing mice as models. The anti-tumor ef- fect of CGP was observed and tumor inhibitory rate and life-prolonging rate were calculated respectively. Results：The inhibitory rate of CGP in high,middle and low doses of S-180 mice were 41.7%,36.2% and 30.7%,the life-prolonging rates of EAC mice were 38.9%,46.7% and 26.4%. Compared with control group, there were significant difference（P〈0.05,P〈0.01）. Conclusion：CGP has anti-tumor effects and prolong the survival time of EAC bearing mice.

关 键 词：马勃多糖 发酵 抗肿瘤 S-180 艾氏腹水瘤 小鼠 

分 类 号：R285.5[医药卫生—中药学]