盐酸万古霉素在人体药代动力学的快速分析  

Fast Analysis of Pharmacokinetics of Vancomycin Hydrochloride in Volunteers

作　　者：任晓娟[1] 陶霞[2] 

机构地区：[1]南通大学附属医院检验科,江苏南通226001 [2]南通大学附属医院药剂科,江苏南通226001

出　　处：《现代检验医学杂志》2014年第1期122-124,共3页Journal of Modern Laboratory Medicine

摘　　要：目的建立盐酸万古霉素在健康人体的药代快速分析方法。方法20名中国健康受试者，男女各半，分别给予盐酸万古霉素1．0g静脉滴注，用HPLC法测定血药浓度；用DAS2．1．1药代动力学程序计算药代动力学参数。结果盐酸万古霉素的主要药代动力学参数：Cmax为（52．16±4．21）mg／L；t/2β为（3．255±0．27）h；AUC0-∞为（148．116±18．25）h·mg／L；AUC。为（133．8±20．13）h·mg／L。结论该方法适合快速分析的盐酸万古霉素药代动力学HPLC方法。Objective To investigate and analysis the pharmaeokineties of vancomycin hydrochloride in Chinese healthy volun- teers. Methods Twenty healthy volunteers （ten males and ten females） were administered with vancomycin hydroehloride 1.0 g intravenously. The concentrtions of vancomyein hydroehloride in plasma were determined by HPLC and DAS 2.1.1 was used to calculate the pharmacokinetic parameters. Results The main pharmacokinetic parameters of vaneomycin hydro- chloride were as follows： C were （52.16±4.21） mg/L,L/2βwere （3. 255±0.27） h,AUC0-∞ were （148. 116±18.25） h · mg/L,AUC0t were （133.8±20.13） h · mg/L. Conclusion This method is suitable for a fast pharmacokinetics HPLC anal- ysis of Vancomycin hydrochloride in Chinese healthy volunteers.

关 键 词：盐酸万古霉素 药代动力学 分析 

分 类 号：R978.1[医药卫生—药品] R969.1[医药卫生—药学]