常规治疗联合孟鲁司特治疗儿童支气管哮喘疗效观察  

Clinical Application of Conventional Treatment Combined with Montelukast in the Treatment of Bronchial Asthma in Children

作　　者：毛丽娟[1] 周招美[1] 

机构地区：[1]江山市人民医院儿科,浙江江山324100

出　　处：《药物流行病学杂志》2014年第3期142-144,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：目的:探讨常规治疗基础上加用孟鲁司特治疗儿童支气管哮喘的临床疗效。方法:76例支气管哮喘住院患儿采用随机数表法分成两组各38例。对照组患儿给予吸氧、化痰、平喘、解痉等常规对症治疗,观察在对照组基础上加用孟鲁司特片。治疗3个月后,观察两组患儿临床疗效、临床症状体征消失时间及住院时间,比较两组治疗前后肺功能改善情况及治疗期间药品不良反应发生情况。结果:治疗后,观察组总有效率为94.74%,高于对照组的76.31%(P<0.05);观察组临床症状体征消失时间及住院时间较对照组显著缩短(P<0.05)。治疗后,观察组肺功能均较前有明显改善(P<0.05),与对照组比较,差异有统计学意义(P<0.05)。两组在治疗的过程中均未见明显不良反应。结论:常规治疗基础上加用孟鲁司特治疗儿童支气管哮喘效果显著,可有效改善患儿临床症状体征及肺功能,缩短住院时间。Objective：To investigate the clinical efficacy of conventional treatment combined with montelukast in the treatment of bronchial asthma in children. Methods：76 cases of bronchial asthma children collected from January to December, 2012 in our hospital were randomly divided into two groups with 38 cases each. The controlled group were given oxygen inhalation, phlegm, relieving asthma, antispasmodic and other conventional symptomatic treatment, and the treatment group were given oral montelukast tablets in the treatment. The clinical curative effect, clinical symptoms disappearance time, hospitalization time and comparison of the improvement of their pulmonary function before and after the treatment amd their adverse drug reactions during the treatment were observed. Methods：After the treatment, the total effective rate of the controlled group was 76.31%, and that of the treatment group was 94.74%. There was statistically significant difference（P〈0.05）. The clinical symptoms and signs disappearance time and hospitalization time of the treatment group were significantly shorter than those in the controlled group. There was statistically significant difference（P〈0.05）. The pulmonary function test of the two groups showed no statistical significance （P〈0.05） before the treatment, but their pulmonary function was improved after it. The improvement of the treatment group was significantly better than that of the controlled group. There was significant difference between the two groups（P〈0.05）. The two group had no significant adverse reactions in the process of treatment.Conclusion：The conventional treatment combined with montelukast had a significant effect on the treatment of children bronchial asthma, which could effectively improve the clinical symptoms and pulmonary function, shorten the time of hospitalization, and had no obvious adverse reactions; therefore, it is worthy of wide clinical application.

关 键 词：孟鲁司特 支气管哮喘 儿童 疗效 

分 类 号：R974.3[医药卫生—药品]