头孢菌素类药致药源性死亡文献分析  

Literature Analysis of Drug-induced Death Caused by Cephalosporins

作　　者：李碧青[1] 

机构地区：[1]广州医科大学附属第四医院,广州511447

出　　处：《药物流行病学杂志》2014年第3期195-197,共3页Chinese Journal of Pharmacoepidemiology

摘　　要：为了解头孢菌菌素类药致药源性死亡的发生情况及特点,检索中国生物医学文献数据库、中国知网、万方数据库和维普网中有关头孢菌素类药致药源性死亡的文献资料,对致死病例的性别、年龄、药物不良反应临床表现及死亡原因等信息进行回顾性分析。结果发现,检索到有效文献52篇,报道病例73例;死者平均年龄(47.12±13.05)岁,男女性别比为1.43:1;原发疾病以呼吸系统感染为主(52例,71.24%);给药方式以静脉滴注为主(63例,86.30%);ADR的发生时间主要集中在10 min以内(47例,64.38%);使用第三代头孢菌素药患者最多(48例,65.75%),使用频率最高的前3位头孢菌素类药依次为:头孢曲松钠24例(32.88%)、头孢唑林钠11例(15.07%)、头孢哌酮钠10例(13.70%);过敏性休克是导致药源性死亡的主要原因(56例,76.71%)。This article aims to investigate the situation and characteristics of drug induced deaths by cephalosporins to provide a scientific basis and ensure drug safety. Chinese Biomedical Literature Database, Chinese HowNet, WANFANG DATA and VIP network related cephalosporins were screened out to find literatures about the fatal cases of drug induced death in respect of sex, age, clinical manifestations of adverse drug reactions, causes of death and other information, which were retrospectively analyzed. The results showed that ： 52 effective references were selected from 2000-2012, and 73 cases, reported. The mean death age was 47.12±13.05 years old, and male to female ratio was 1.43∶1. The respiratory infections were the main causes of the primary disease dominating 71.24%（52 cases）, and the route of the drug administration was mainly the intravenous injection, accounting for 86.30%（63 cases）. ADR occurrence mainly occurred within 10min or less （47 cases, 64.38%）. Most patients used the third generation cephalosporins （48 cases, 65.75%）, the front three drugs most frequently used were ceftriaxone （24 cases, 32.88%）, cefazolin （11 cases, 15.07%） and cefoperazone （10 cases, 13.70%）. Anaphylactic shock was the main cause of death （56 cases, 76.71%）. So more attention should be paid to adverse cephalosporin reactions to promote cephalosporin skin test work, ensure drug safety and prevent deaths occur.

关 键 词：头孢菌素 药源性死亡 抗菌药 

分 类 号：R978.11[医药卫生—药品]