线粒体TOM系统在心血管疾病中的研究现状  

Research on mitochondrial translocase of outer mitochondrial membrane complex in cardiovascular diseases

作　　者：薛强[1] 裴海峰[1] 段海霞[2] 卫飞鹏[3] 闫柄文 王伟[4] 陶凌[1] 

机构地区：[1]第四军医大学西京医院心血管内科,陕西西安710032 [2]西安交通大学医学院附属广仁医院,陕西西安710004 [3]第四军医大学唐都医院介入科,陕西西安710038 [4]解放军305医院医务部,北京100017

出　　处：《心脏杂志》2014年第2期214-217,221,共5页Chinese Heart Journal

基　　金：国家杰出青年基金资助(81225001)

摘　　要：线粒体内稳态的维持与其内部蛋白密切相关,而绝大多数蛋白进入线粒体内部发挥作用均需通过线粒体的线粒体外膜转位酶(translocase of the outer mitochondrial membrane,TOM)系统的转运。研究表明,线粒体TOM系统相关组成亚基Tom70、Tom20和Tom40等参与了心血管疾病的发生发展,这为我们从线粒体蛋白水平研究心血管疾病的机制及开发新的治疗措施提供了思路。本文针对线粒体TOM系统在心血管相关疾病(如心肌缺血/再灌注、高血压及心功能衰竭)方面的研究现状进行了综述。Mitochondrial homeostasis is closely related to its internal proteins. The mitochondrial inner translocase of the outer mitochondrial membrane （TOM） transport system plays a role for proteins to import into mitochondria. Studies have shown that subunit compositions of mitochondrial TOM system such as TomT0, Tom20 and Tom40 participate in the initiation and development of cardiovascular diseases, which provides us new ways to elucidate the pathogenesis and to develop therapies. This article focuses on the main findings of TOM system in cardiovascular diseases such as myocardial ischemia/reperfusion, hypertension, and heart failure.

关 键 词：线粒体 线粒体外膜转位酶系统 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]