肺癌患者外周血淋巴细胞亚群与预后的关系  

The correlation of peripheral blood lymphocyte subsets with prognosis in lung cancer patients

作　　者：魏熙胤[1] 张翠翠[1] 臧凤琳[1] 李凯[1] 

机构地区：[1]天津医科大学肿瘤医院肿瘤研究所公共实验室,国家肿瘤临床医学研究中心,天津市肿瘤防治重点实验室,天津市300060

出　　处：《中国肿瘤临床》2014年第6期390-393,共4页Chinese Journal of Clinical Oncology

基　　金：天津市科委抗癌重大专项攻关计划(编号:12ZCDZSY15600)资助~~

摘　　要：目的:探讨肺癌患者外周血T细胞亚群及NK细胞与临床病理特征及预后的关系。方法:回顾性观察102例肺癌患者、12例肺良性疾病患者及23例健康体检者,记录其外周血T细胞亚群及NK细胞占外周血淋巴细胞的百分比,对比二者分布在肺癌、肺良性疾病及健康体检者之间的差异,并对患者的临床病理资料进行回顾性分析,分析淋巴细胞亚群与预后的关系及其与临床病理特征的相关性。结果:肺癌患者外周血CD4+T细胞低于健康体检者,而CD8+T细胞却较高,差异有统计学意义(P<0.05);单因素分析显示T细胞亚群及NK细胞分布与预后并无显著关系(P>0.05),而与淋巴结转移、TNM分期、肿瘤标志物等存在相关性(P<0.05)。结论:肺癌患者外周血T亚群及NK细胞分布异常,动态监测患者外周血T细胞亚群及NK细胞有助于评估患者免疫功能,有望成为判断患者预后的一种指标。Objective： To study the relationship of lymphocyte subsets with prognosis and clinico-pathologic features in lung can-cer patients. Methods： Flow cytometry was used to analyze the distribution of T-lymphocyte subsets and natural killer cells in the pe-ripheral blood of lung cancer patients, patients with benign pulmonary diseases, and healthy controls. The peripheral-blood lymphocyte levels of the subjects were compared. Clinical data obtained from 102 lung cancer cases were reviewed retrospectively, and the relation-ship of lymphocyte subsets with prognosis and clinico-pathologic features was analyzed. Results： The level of CD4＋ T cells was lower in the peripheral blood of lung cancer patients than that of the healthy controls （P〈0.05）; however, the level of CD8＋ T cells was higher in lung cancer patients than in the healthy controls （P〈0.05）. Univariate analysis revealed that T-lymphocyte subsets and natural killer cells were not influential factors in the overall survival of lung cancer patients （P〉0.05）. However, the abnormal distribution of lympho- cyte subsets was related to lymphatic metastasis, TNM stage, and tumorigenesis P〈0.05）. Conclusion： The distribution of T-lympho-cyte subsets and natural killer cells was abnormal in the peripheral blood of lung cancer patients, and the dynamic changes in distribu-tion can help assess the immune functions of lung cancer patients. Cellular immune function can act as a prognostic indicator in lung cancer patients.

关 键 词：肺癌 细胞免疫 淋巴细胞亚群 预后 

分 类 号：R734.2[医药卫生—肿瘤]