低强度超声对早孕大鼠药物流产后阴道流血和子宫组织缩宫素受体表达的影响  

Effect of Low-intensity Ultrasound to Vaginal Bleeding and Expression of Oxytocin Receptor in SD Rats Uterinus Muscular after Medical Abortion

作　　者：张艳霞[1] 郭菊芳[1] 林川[1] 陆露[1] 李成志[1] 王志彪[1] 

机构地区：[1]重庆医科大学生物医学工程学院,省部共建超声医学工程国家重点实验室,超声医学工程重庆市重点实验室,重庆市400016

出　　处：《中国超声医学杂志》2014年第3期277-280,共4页Chinese Journal of Ultrasound in Medicine

基　　金：“十二五”国家科技支撑计划项目(No.2011BAI141301)

摘　　要：目的观察低强度超声对早孕大鼠药物流产后阴道流血和子宫组织缩宫素受体(OTR)表达的影响。方法建雌性早孕大鼠药流模型30只,随机分成治疗组和对照组,治疗组给予低强度超声治疗30 min/d,共5 d;对照组采用与治疗组相同的操作方法进行治疗,但仪器无功率输出,治疗期间观察阴道流血量和流血时间。5 d后取子宫组织,采用免疫组化SP法检测OTR含量。结果治疗组阴道流血量少于对照组,差异有统计学意义(P<0.05),但流血时间两组无差异;子宫肌层和内膜层治疗组OTR强阳性表达率均高于对照组,差异有显著统计学意义(P<0.05)。结论低强度超声可促进产后子宫复旧;其促进子宫复旧的机制与增加子宫肌层和内膜层细胞的缩宫素受体表达有关。Objective To observe the effect of Low-intensity ultrasound to vaginal bleeding and expression of ox ytocin receptor in uterinus muscular of SD rats after medical abortion. Methods 30 female pregnancy rats were ran domly divided into treatment group and control group . Treatment group was treated by low-intensity ultrasound for 30 min/d ,5 days. Control group was treated by the same methods with treatment group . But, no power output dur- ing the treatment. Observe the amount of vaginal bleeding and bleeding time during treatment. Uterine tissue was taken out after 5 days. OTR was detected by immunohistochemistry. Results Vaginal bleeding was less in treatment group than that in control group. The difference was statistically significant （P〈0.05） ; Strong positive expression rate of OTR was higher in treatment group than that in control group in myometrium and endometrium of uterus（P〈 0.05）. Conclusions Low-intensity ultrasound can promote postpartum uterine involution. And its Mechanisms was related to increase expression of oxytocin receptor in myometrium and endometrium of uterus.

关 键 词：低强度超声 流血量 流血时间 缩宫素受体 

分 类 号：R445.1[医药卫生—影像医学与核医学] R169.4[医药卫生—诊断学]