1606例新生儿败血症病原菌分布及其耐药性分析  

Analysis of pathogen distribution and antibiotic resistance in 1606 blood cultures from neonates

作　　者：唐晓娟[1] 冯星[1] 

机构地区：[1]苏州大学附属儿童医院新生儿科,江苏苏州215003

出　　处：《临床儿科杂志》2014年第3期210-213,共4页Journal of Clinical Pediatrics

基　　金：国家自然科学基金面上项目(No.81271378);江苏省自然科学基金项目(No.BK2011311)

摘　　要：目的研究败血症新生儿的病原菌分布及其耐药情况。方法回顾性分析2002年至2012年间收入新生儿重症监护病房的新生儿血培养及其药敏分析结果。结果共28 120份新生儿血培养标本中培养阳性1 606份(5.7%),共培养出病原菌1 665株;其中革兰阳性菌1 336株,以表皮葡萄球菌(902株)及溶血性葡萄球菌(206株)为主;革兰阴性菌235株,以肺炎克雷伯杆菌(108株)及大肠埃希菌(73株)为主。逐年比较,不同菌株的检出率差异有统计学意义(P<0.05)。2012年175株病原菌的药敏结果显示,革兰阳性菌对利奈唑胺、替加环素和万古霉素的敏感率高,对青霉素耐药性达90%以上;革兰阴性菌对阿米卡星及亚胺培南敏感性高,对氨苄西林的耐药性较高。结论表皮葡萄球菌、溶血性葡萄球菌、肺炎克雷伯杆菌及大肠埃希菌是新生儿败血症的主要病原菌,且普遍对青霉素耐药。Objective To determine the pathogen profile and antibiotic resistance in aerobic isolates from blood cultures of neonates. Methods All blood culture reports （n=28120） from newborns admitted to the Department of Neonatology during 2002-2012 were analyzed, and the sensitivity patterns were recorded. Results A total of 1665 bacteria were isolated from 1606 blood culture-positive samples and the positive rate of blood cultures was 5.7% （1606/28120）. Gram-positive bacteria were isolated in 1336 cases, with Staphylococcus epidermidis （902 cases） and Staphylococcus haemolyticus （206 cases） being the common bacteria. Klebsiella pneumoniae （108 cases）, followed by Escherichia coli （73 cases）, were the major Gram-negative bacteria （235 cases）. The determination of the antibiotic resistance of aerobic isolates was performed in 2012. Most Gram-positive isolates were sensitive to vancomycin and moxifloxacin, and more than 90% were resistant to penicillin while most of Gram-negative isolates were sensitive to amikacin and imipenem. Conclusions Staphylococcus epidermidis, Staphylococcus haemolyticus, Klebsiella pneumoniae and Escherichia coli remain to be the principal organisms responsible for neonatal sepsis.

关 键 词：新生儿败血症 血培养 耐药性 

分 类 号：R446.5[医药卫生—诊断学]