新生儿败血症的病原菌分布及耐药性分析  

Distribution and drug resistance of pathogens in 132 cases of neonatal sepsis

作　　者：陈婷[1,2] 陆勤[1] 杨力[1] 徐文君[1] 史明霞 

机构地区：[1]南京医科大学附属南京妇幼保健院,江苏南京210004 [2]南京医科大学公共卫生学院,江苏南京211166

出　　处：《临床儿科杂志》2014年第3期220-223,共4页Journal of Clinical Pediatrics

基　　金：南京市医学科技发展资金资助项目(No.QRX11222);南京医科大学科技发展基金资助项目(No.2012NJMU207)

摘　　要：目的了解新生儿败血症常见病原菌分布及耐药性。方法回顾性分析2012年1月至2013年6月收治的132例新生儿败血症的血培养及药敏试验结果。结果共分离出病原菌132株，其中革兰阳性菌100株（75.76％），革兰阴性菌30株（22.73％），真菌2株（1.52％）。排在前3位的细菌分别为表皮葡萄球菌、大肠埃希菌、金黄色葡萄球菌。革兰阳性球菌对青霉索耐药率均为100.00％，对红霉素、复方磺胺甲嗯唑和氨苄西林，舒巴坦的耐药率较高（62.50％-100.00％），对万古霉素和替考拉宁尚未发现耐药。革兰阴性杆菌对氨苄西林普遍耐药（100.00％），对头孢曲松、复方磺胺甲嗯唑和头孢呋辛的耐药率较高（61.54％～100.00％），对亚胺培南和哌拉西林／他唑巴坦的耐药率较低。结论新生儿败血症治疗应根据血培养和药敏试验结果选择合适的抗菌药物。Objective To investigate the distribution and antibiotic resistance of isolated pathogens in neonatal sepsis. Methods The results of blood culture and drug susceptibility test in neonates sepsis from January 2012 to June 2013 were retrospectively analyzed. Results One hundred and thirty-two strains were detected in the blood samples, with 100 （75.76%） Grampositive bacteria, 30 （22.73%） Gram-negative bacteria and 2 （1.52%） fungus. Staphylococcus epidermidis, Escherichia coli and Staphylococcus aureus were the three most common pathogens. Gram-positive cocci was strongly resistant to penicillin （100.00%）, erythromycin, selectrin and ampicillin/sulbactam （62.50%-100.00%）, but still sensitive to vancomycin and teicoplanin. The resistance rate of Gram-negative bacilli to ampicillin was 100.00%, and the resistance rate to cefatriaxone, selectrin and cefuroxime was 61.54%-100.00%. The resistance rate to imipenem and piperacillin/tazobactam was lower. Conclusions The selection of sensitive antibiotics should be based on the pathogens and drug resistance testing for the treatment of neonatal sepsis.

关 键 词：败血症 病原菌 耐药性 新生儿 

分 类 号：R722.1[医药卫生—儿科]