miR-150与临床疾病研究的新进展  

New advances of miR-150 and diseases

作　　者：刘付梅[1] 李祥勇[1] 周克元[1] 

机构地区：[1]广东医学院生物化学与分子生物学研究所,湛江医学硕士研究生524023

出　　处：《医学研究生学报》2014年第2期194-198,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(81172067);东莞市高等院校科技计划一般项目(2011108102044);湛江市科技攻关项目(2011C3108012)

摘　　要：microRNA(miRNA)是一种新型的小分子非编码RNA,对基因表达具有非常重要的调控作用。miR-150是一个长度为22个核苷酸的非编码小分子RNA,定位于人类染色体19q13.33,主要通过调控其靶基因的表达,在免疫系统、造血系统发生、胚胎发育和干细胞分化中发挥重要作用,并在许多疾病中发生异常表达,提示miR-150与疾病的发生与发展密切相关。本文就miR-150在人体正常生理过程中的作用以及异常表达引起的机体变化和可能的作用机制作一综述。MicroRNA （miRNA）is a novel type of non-coding RNA which can play very important roles in regulating gene expression. Early studies found that miR-150 is a 22 nt non-coding RNA, and located on Chromosome 19. It plays key roles in immune system, hematopoietic system progressive, embryonic development and stem cells differention by regulating the expression of its target mRNA. Recent investigations suggest that miR-150 expresses abnormally in different diseases. This reveals that miR-150 is closed related to the occurrence and development of many diseases. This article reviews the effect of miR-150 in human normal physiological processes, its abnormal expressions inducing changes in body and the possible mechanism involved.

关 键 词：miR-150 临床疾病 基因表达调控 

分 类 号：Q344.13[生物学—遗传学]