多囊卵巢综合征患者妊娠期血清、胎盘局部雄激素水平的检测及评价  

Serum and placental testosterone levels in patients with polycystic ovary syndrome

作　　者：赵楠楠 崔毓桂 刘嘉茵 

机构地区：[1]江苏南京医科大学第一附属医院,南京201129

出　　处：《生殖医学杂志》2014年第3期229-232,共4页Journal of Reproductive Medicine

基　　金：国家973项目(2012CB944902;2012CB944703)

摘　　要：目的了解多囊卵巢综合征(PCOS)患者行体外受精-胚胎移植(IVF-ET)治疗后,妊娠期胎盘局部是否存在雄激素水平的升高,并探讨胎盘局部高雄激素水平与PCOS患者不良妊娠结局的关系。方法 17例PCOS行IVF-ET治疗后妊娠患者为观察组,19例非遗传学因素(输卵管因素,流产后继发不孕)行IVF-ET治疗后妊娠患者为对照组,采用放射免疫分析法(RIA)、酶联免疫吸附法(ELISA)对其外周血、胎盘组织局部总睾酮(TT)、性激素结合球蛋白(SHBG)等指标进行测定。并根据外周血雄激素水平,将观察组分为高雄组(n=12)及非高雄组(n=5)。结果 PCOS高雄患者妊娠期外周血及胎盘局部TT、游离睾酮指数(FAI)较对照组及非高雄组明显升高,且有显著性差异(P均<0.001);PCOS高雄组SHBG较对照组及非高雄组稍有降低,但无显著差异(P>0.05)。结论具有高雄激素血症的PCOS患者胎盘局部雄激素水平升高。Objective： To investigate whether androgen levels are elevated in the placenta of polycystic ovary syndrome（PCOS） patients undergone in vitro fertilization-embryo transfer treatment, and explore the relationship between androgen levels and adverse pregnancy outcomes in PCOS. Methods： Serum and placenta total testosterone（TT）and sex hormone binding globulin（SHBG）levels were measured by radioimmunoassay in 36 pregnant women undergone in vitro fertilization-embryo transfer treatment. Among them, 17 patients with PCOS patients were as investigating group, and 19 non-PCOS patients with non-genetic factors such as oviduct factors or secondary infertility after abortion were as control group. The PCOS patients were subgrouped into hyperandrogenism group （n =12） and non- hyperandrogenism group （n=5）, according to the serum androgen levels. Results： The serum and placenta total testosterone levels and free androgen index （FAI）were significantly higher in hyperandrogenism group than those in control group or non-hyperandrogism group （P〈0. 001 ,for all）. The SHBG levels were lower in hyperandrogism group than those in control group or and hyperandrogenism. ovary syndrome

关 键 词：多囊卵巢综合征 高雄激素血症 性激素结合球蛋白 游离睾酮指数 

分 类 号：R4[医药卫生—临床医学]