甲基强的松龙对体外循环心内直视手术临床疗效影响的研究  

Study on clinical benefit of methylprednisolone use in patients undergoing cardiopulmonary bypass

作　　者：信红雁[1] 刘美明[1] 霍玉峰[1] 邹丽霞[1] 魏雪[1] 

机构地区：[1]山东省胸科医院心外科,山东济南250013

出　　处：《泰山医学院学报》2013年第11期826-828,共3页Journal of Taishan Medical College

摘　　要：目的探讨甲基强的松龙对体外循环心内直视手术患者临床疗效的影响。方法体外循环心内直视手术患者173例,随机分为甲基强的松龙组(A组)和对照组(B组),分别为86例和87例。A组术中在体外循环预充液中给予甲基强的松龙3.2 mg/kg,B组术中在体外循环预充液中给予生理盐水3.2 mg/kg,比较两组患者术后心房颤动发生率、手术后机械通气时间、重症监护时间、住院时间、术后24 h心包纵隔引流量、术后患者的病死率及感染发生率等参数方面的不同。结果 A组心房颤动发生率小于B组(18.6%vs 37.9%,P<0.01);A组手术后机械通气时间、重症监护时间和住院时间均短于B组(P<0.05);术后24 h心包纵隔引流量两组间差异有统计学意义(P<0.01)。A组和B组病死率及感染发生率相比无明显区别。结论甲基强的松龙能够明显提高体外循环心内直视手术术后的治疗效果。Objective： To explore the clinical benefit of methylprednisolone use in patients undergoing cardiopulmonary bypass. Methods ：173 patients undergoing cardiac surgery with CPB were randomly divided into the two groups,with 86 pa- tients in methylprednisolone group（ Group A） and 87 patients in control group （Group B）. Patients of Group A received methylprednisolone （3.2 mg/kg） and Patients of Group B received Saline （3.2 mg/kg）. Results：Methylprednisolone had a protective effect on preventing postoperative atrial brillation, reducing ventilation duration, reducing intensive care unit and overall hospital stay, and reducing drainage dose of pericardium and mediastinum in post operative 24 h. But Methyl- prednisolone had no effect on postoperative mortality and postoperative infection. Conclusion： Patients undergoing eardiopul- monary bypass can be enhanced significantly in clinical benefit by methylprednisolone.

关 键 词：甲基强的松龙 糖皮质激素 体外循环 临床疗效 

分 类 号：R654.1[医药卫生—外科学]