探索口腔内疼痛性冷水刺激时对眶额皮层激活的影响  

Effects of nociceptivecoldon activation of orbitofrontal cortex during intraoral stimuli with water

作　　者：杨秀文[1] 刘洪臣[2] 李科[3] 金真[3] 李刚[3] 

机构地区：[1]解放军总医院口腔种植科,副主任医师北京100853 [2]解放军总医院口腔医学研究所 [3]解放军第306医院医学影像科磁共振室,主治医师北京100101

出　　处：《中华老年口腔医学杂志》2013年第5期262-264,共3页Chinese Journal of Geriatric Dentistry

基　　金：国家自然科学基金资助项目(30572066);首都医学科研发展基金重点资助项目(2002-2018)

摘　　要：目的:探索疼痛性冷水刺激口腔时脑功能活动的影响。方法:选取健康志愿者6例,利用水传递装置用4℃水刺激口腔,并以室温水组作为空白对照。并采集全脑血氧水平依赖对比的功能性磁共振成像(functional magnetic resonance imaging,fMRI)扫描数据。结果:与对照组比较,6例志愿者中冷水刺激均出现眶额皮层的显著激活。结论:发现了疼痛性冷刺激口腔时可激活与疼痛情绪有关的眶额皮层。Objective： To explore effects of nociceptive coldon cerebral cortical activation during intraoral stimulus with water with functional magnetic resonance imaging（fMRI）. Methods： Six healthy volunteers were selected to receive 4℃ water intraoral stimuli through water-delivery, and block designed and blood oxygenation level-dependent （Bold） fMRI scan covering the whole brain were carded out. And 23℃ water L is as a control. Result： There was rebust activation in orbitofrontal cortex among 6 volunteers. Conclusions： The research show orbitofrontal cortex, which is related to human affective/emotion of pain, is activated by nociceptive cold during intraoral stimuli with water.

关 键 词：眶额皮层 疼痛 功能性磁共振成像 口腔内 冷刺激 

分 类 号：R445.2[医药卫生—影像医学与核医学]