突触可塑性相关蛋白的研究进展  

An Update on Key Proteins Involved in Synaptic Plasticity

作　　者：郭敏[1] 李刚[1] 

机构地区：[1]内蒙古医科大学药学院

出　　处：《神经药理学报》2013年第6期57-64,共8页Acta Neuropharmacologica

基　　金：国家自然科学基金项目(No.81260650)

摘　　要：突触可塑性不仅是学习和记忆的细胞分子学基础,同时也是神经系统疾病信号转导的分子机制。突触是突触可塑性变化的敏感部位,在突触前、后膜积聚了许多可导致突触可塑性调节的信号分子,突触部位的这些分子对于神经传递是非常必要的。近年来对于突触可塑性机制的研究主要集中在突触前和突触后相关蛋白以及神经元细胞骨架蛋白等在信号通路中的作用,该文就突触可塑性密切相关蛋白的最新研究进展进行综述。Synaptic plasticity is not only the molecular basis of learning and memory,but also the molecular mechanisms of signal transduction in the nervous system diseases. The synapse are sensitive parts in synaptic plasticity,and presynaptic and postsynaptic membrane accumulates many signal molecules that can lead to the regulation of synaptic plasticity. These molecules are critical for neural transmission in synaptic sections. Recently,the research on the mechanisms of synaptic plasticity is mainly focuses on the functions of proteins involved in presynaptic and postsynaptic plasticity and the neural cytoskeletal proteins in key signal pathways.

关 键 词：突触可塑性 蛋白 研究进展 

分 类 号：Q427[生物学—神经生物学]