Th17与1型糖尿病  

Th17 in type 1 diabetes mellitus

作　　者：李艳玲[1] 崔焕焕[1] 王坚[1] 

机构地区：[1]南方医科大学南京临床学院南京军区南京总医院内分泌科,210002

出　　处：《中华临床医师杂志（电子版）》2013年第24期279-281,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金(81370922)

摘　　要：1型糖尿病是一种以选择性易感人群胰岛β细胞损害、胰岛素分泌绝对减少为特征的自身免疫性疾病。其发病率在全球持续增长,每300人当中就有1人患有1型糖尿病。1型糖尿病的病因和发病机制较复杂,至今仍未完全明确,认为其与自身免疫紊乱密切相关,近年来有研究认为其发病与Th17密切相关,本文将Th17的相关特征及其介导1型糖尿病发病的机制进行综述。Type 1 diabetes mellitus （T1DM） is a kind of autoimmune diseases, which is selective susceptible isletβcells damage and with an absolute reduction of insulin secretion. Its incidence increased year by year in the world, there will be a person with T1DM in 300 people. The etiology and pathogenesis of TIDM is so complex, and is still not clear. A large number of researchers believe that it is closely related with autoimmune disorders, recent studies suggest that its incidence is closely related with Th17. This article will introduce Th17 related features, as well as the possible mechanism of Th17 mediate T1DM.

关 键 词：糖尿病 1型 自身抗原 TH17 胰岛Β细胞 

分 类 号：R587.1[医药卫生—内分泌]