Apelin与糖尿病及其血管并发症相关性研究进展  

The correlation of Apelin with diabetes, diabetes complications, and its comorbid disease

作　　者：陈薇[1] 赵晓娟[1] 王楠楠[1] 

机构地区：[1]中国医科大学附属第一医院内分泌科,沈阳110010

出　　处：《中华临床医师杂志（电子版）》2013年第24期314-316,共3页Chinese Journal of Clinicians(Electronic Edition)

基　　金：辽宁省科学技术计划项目(2009225010-10)

摘　　要：胰岛功能缺陷与胰岛素抵抗是2型糖尿病发病的两个关键因素。近年研究认为,氧化应激、炎症反应与脂肪内分泌相互作用,从而引起胰岛素抵抗和β细胞功能障碍。因此,对上述机制进行干预成为实验研究及临床治疗的一个热点。脂肪因子Apelin具有影响胰岛素敏感性、影响心血管功能、抗炎及抗氧化应激等作用。本文就Apelin与糖尿病、糖尿病血管并发症的关系展开综述。Islet B cell function defect and insulin resistance are two key factors for type 2 diabetes. Recent studies suggest that the interaction of oxidative stress, inflammation, and fat endocrine cause insulin resistance and beta cell dysfunction. Therefore, the intervention of above mechanism become a focus in the experimental study and clinical treatment. The fat factor--Apelin influences insulin sensitivity and cardiovascular function, anti-inflammatory and anti-oxidative stress, and so on. The relationship between Apelin and diabetes, vascular complications of diabetes were summarized in this review.

关 键 词：糖尿病 糖尿病肾病 糖尿病视网膜病变 高血压 冠心病 APELIN 

分 类 号：R587.1[医药卫生—内分泌]