In Vivo Anti-Inflammatory Assessment of Quillaja saponaria Mol. Extracts  

作　　者：Mait6 Rodriguez-Diaz Olosmira Correa Carlos Cartagen Bruce K. Cassels CarlaDelporte 

机构地区：[1]Faculty of Medicine, Universidad Andres Bello, Santiago 8370134, Chile [2]Department of Pharmaceutical Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago1058, Chile [3]Department of Pharmacological and Toxicological Chemistry, Faculty of Chemical and Pharmaceutical Sciences, University ofChile, Santiago 1058, Chile [4]Department of Chemistry, Faculty of Sciences, University of Chile, Santiago 1058, Chile

出　　处：《Journal of Life Sciences》2013年第12期1243-1248,共6页生命科学（英文版）

摘　　要：Aqueous extracts from the native Chilean Quillaja saponaria tree are used orally and topically to treat lung inflammatory problems and toothache. This study aimed to corroborate their presumed anti-inflammatory activity, identify their active ingredients and validate their use. The topical anti-inflammatory activity of a commercial partially purified Quillaja saponin aqueous extract （Ultra Dry 100Q, UD）, the crude acid hydrolysate （H-100Q） of this material, its two most abundant sapogenins QA （quillaic acid） and PA （phytolaccagenic acid）, and two formulations containing QA were subjected to topical assays for the inhibition ofmurine ear inflammation elicited by AA （arachidonic acid） or TPA （phorbol ester）. The dose-dependent anti-inflammatory activity of QA was confirmed in both AA （maximal effect 92.1%） and TPA （maximal effect 62.2%） assays, and PA showed significant anti-inflammatory activity against AA （46.5%）. Two dermo pharmaceutical formulations containing 8% w/v QA as the active ingredient--a cream and a gel--also exhibited significant anti-inflammatory effects in the TPA （50.8%） and AA （39.5%） assays.

关 键 词：Quillaja saponaria TRITERPENOIDS quillaic acid phytolaccagenic acid topical anti-inflammatory activity phorbol acetate arachidonic acid. 

分 类 号：TQ463.3[化学工程—制药化工] TS202.3[轻工技术与工程—食品科学]