复方敏维糖浆对慢性荨麻疹患者血清白细胞介素-4和干扰素-γ的影响  

Effect of compound Minwei syrup on serum IL-4 and IFN-γ in patients with chronic urticaria

作　　者：王国辉[1] 王建茹[1] 王艳会[1] 张立新[1] 贾慧军[1] 王春艳[1] 于桂兰[1] 

机构地区：[1]唐山市妇幼保健院药剂科,河北省唐山063000

出　　处：《中国基层医药》2014年第6期834-835,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨复方敏维糖浆对慢性荨麻疹患者血清IL-4和干扰素-γ（IFN-γ）的影响.方法 189例慢性荨麻疹患者作为观察组,60例非过敏性疾病患者作为对照组,对观察组进行复方敏维糖浆治疗,平均治疗7d.治疗前后测定两组血清IL-4和IFN-γ,观察不良反应.结果 经治疗后,观察组痊愈123例,显效34例,有效23例,无效9例,总有效率为95.2％;观察组治疗前血清IL-4较对照组明显升高（t=3.729,P＜0.01）、IFN-γ较对照组明显降低（t=3.064,P＜0.01）;观察组治疗后血清IL-4比治疗前明显降低（t=2.778,P＜0.05）、IFN--y比对照组明显升高（t=2.467,P＜0.05）.观察组出现轻度嗜睡、困倦2例,停药后症状消失.结论 复方敏维糖浆可明显改善慢性荨麻疹患者的IL-4和IFN-γ平衡.[ Abstract] Objective To study the effect of compound Minwei syrup on serum interleukin-4 （IL-4） and interferon--γ（IFN-γ） in patients with chronic urticaria. Methods 189 patients with chronic urticaria were enrolled as the observation group,60 cases of non-allergic diseases were selected as the control group. The observation group was treated by compound Minwei syrup for average 7 days. Serum levels of IL-4 and IFN-γbefore and after treatment were detected. Results After treatment, in the observation group 123 cases recovered, 34 cases had marked effect, effec- tive in 23 cases,9 cases without effect, the total effective rate was 95.2%. Serum IL-4 in the observation group before treament was significantly higher than the control group（ t = 3. 729, P 〈 0.01 ）, IFN-γ was significantly lower than the control group （ t = 3. 064, P 〈 0.01 ）. After treatment, serum IL-4 in the observation group was significantly lower than before treatment （ t=2. 778, P 〈 0.05 ）, IFN-~/was significantly higher than the control group （ t = 2. 467, P 〈 0.05 ）. Mild drowsiness and sleepiness appeared in 2 patients in the observation group, symptoms disappeared after drug with- drawal. Conclusion Minwei syrup can significantly improve IL-4 and IFN-γ, balance in patients with chronic urticaria.

关 键 词：荨麻疹 复方敏维糖浆 白细胞介素4 干扰素-Γ 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]