特发性肺纤维化“肺肾阴虚、痰瘀伏络”病机探识  

Discussion on the pathogenesis of “Yin deficiency of lung-kidney and Phlegm in meridian” in idiopathic pulmonary fibrosis

作　　者：石晓乐[1] 曲妮妮[2] 庞立建[2] 刘创[1] 

机构地区：[1]辽宁中医药大学,沈阳110032 [2]辽宁中医药大学附属医院,沈阳110032

出　　处：《吉林中医药》2014年第3期220-222,共3页Jilin Journal of Chinese Medicine

基　　金：国家自然基金项目(81373579);国家中医药管理局(中医络病重点学科建设项目);辽宁省科学计划项目(2012020108-202)

摘　　要：历代医家多数将特发性肺纤维化归属中医"肺痿"范畴,对其病机认识多宗仲景"肺燥津亏、肺气虚冷"论。基于此理论,参照现代医学对特发性肺纤维化发病机制的研究来探索特发性肺纤维化的根本病机。肺易感受燥热之邪,燥热伤阴,而虚冷之证多从阴虚内热演变而来。肺阴亏虚,必劫肾阴以助;肾阴不足,必致肺阴易虚。而病久成瘀生痰,伏于络脉。由此总结特发性肺纤维化的病机为"肺肾阴虚,痰瘀伏络",以期为创新特发性肺纤维化的中医防治思路,提高其临床疗效奠定理论基础。Most ancient physicians attribute idiopathic pulmonary fibrosis to traditional Chinese medicine ＂pulmonary flaccid- ity＂ category.Their understanding of the pathogenesis was based on Zhongjing ＂Feizao Jin Kui and deficiency and coldness of Qi＂. Based on this, referring to the modem medical research on the pathogenesis of idiopathic pulmonary fibrosis, the basic pathogenesis of idiopathic pulmonary fibrosis is explored. Lung is very susceptible to dryness heat, which does harm to Yin. The deficiency and cold syndrome comes from Yin deficiency. Yin deficiency of lung leads to Yin deficiency of kidney; and it may lead to blood stasis and phlegm in collaterals. The pathogenesis of idiopathic pulmonary fibrosis is ＂Yin deficiency of lung-kidney and phlegm in meridian＂, which lays the theoretical foundation for the innovative ideas of prevention and treat- ment of TCM of idiopathic pulmonary fibrosis and improvement of its clinical efficacy.

关 键 词：特发性肺疾病 间质性肺纤维化 肺痿 病机 痰瘀相关 肺肾阴虚 

分 类 号：R563[医药卫生—呼吸系统]