汉族人群醛固酮合成酶CYP11B2基因多态性位点(rs1799998)与原发性高血压相关性研究的Meta分析  

The association between rs1799998 of aldosterone synthase gene(CYP11B2) and essential hypertension:an update meta-analysis

作　　者：王丽娟[1] 周家蓬[2] 刘洁琳[1] 张蓓[1] 李梅[1] 李闯[1] 温绍君[1] 

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所高血压研究室,北京100029 [2]北科院北京市计算中心

出　　处：《心肺血管病杂志》2014年第2期214-219,共6页Journal of Cardiovascular and Pulmonary Diseases

基　　金：北京市自然科学基金(7120001;7133232);国家自然科学基金(81270216);北京市科学技术研究院海外人才专项(OTP-2011-011;OTP-2012-011)

摘　　要：目的:评价醛固酮合酶CYP11B2基因多态性位点rs1799998与原发性高血压(EH)的关系。方法:检索PubMed、EmBase、中国期刊全文数据库、中国生物医学文献数据库、维普中文期刊数据库及万方数据库。检索时间范围至2013年11月之前的所有文献。采用RevMan和R软件进行定量分析、计算汇总OR值、发表偏移、敏感性分析及累计Meta分析等。结果:分别检索到研究我国汉族人群CYP11B2基因rs1799998位点与EH相关性的文献42篇,按入选/排除标准筛选后共有17篇合格文献入选,涉及5 835例EH患者,5278例健康对照者。结论:未发现CYP11B2基因rs1799998位点与EH在中国汉族人群中具有明显相关性。Objective：To evaluate the relationship between rs1799998 of aldosterone synthase gene （CYP11B2） and essential hypertension （EH） among the Han Chinese population.Methods：We conducted a retrieval of PubMed,EmBase,CNKI,Wanfang and VIP databases prior to Nov 2013.Articles investigating the relationship of EH and rs1799998 of CYP11 B2 gene of Han group were found trough literature search,including 17 articles,5835 EH vs 5278 controls.The association was examined by RevMan 5.1 and R software.We also performed heterogeneity analysis and sensitivity analysis.Results：We did not find any association between rs1799998 of CYP11 B2 and EH,even in southern and northern Han subgroup.Conclusion：In the recent studies＇ condition,there were not enough evidence to support the hypothesis that rs1799998 was associated with EH.

关 键 词：醛固酮合成酶 高血压 原发性 基因多态性 META分析 

分 类 号：R544.11[医药卫生—心血管疾病]