化学修饰法制备光敏性壳聚糖胶束及其光响应特性  

Construction of Chitosan Micelles by Chemical Modification Method and Their Photo-Responsive Characteristics

作　　者：王双萍[1] 袁方[1] 蒋宏亮[1] 王利群[1] 

机构地区：[1]浙江大学高分子科学与工程学系,杭州310027

出　　处：《功能高分子学报》2014年第1期17-22,共6页Journal of Functional Polymers

基　　金：国家自然科学基金(21174125)

摘　　要：首先通过在壳聚糖氨基上键合环氧丙醇,得到具有良好水溶性与油溶性的缩水甘油壳聚糖(GC),然后用琥珀酰化7-二乙基氨基-4-羟甲基香豆素作为光敏剂修饰GC制得壳聚糖衍生物SCGC,它具有光触发解组装性能。采用FT-IR与1 H-NMR对所得壳聚糖衍生物(SCGC)的结构进行表征,通过跟踪胶束在紫外光照下粒径与Zeta电位的变化研究SCGC的光敏性。结果表明:SCGC具有预期的化学结构,在水中可组装成胶束,芘荧光探针法测得胶束的临界聚集浓度(CAC)为0.07mg/mL。随光照时间的延长,SCGC胶束粒径不断增大,胶束表面负电性也随之增强。Glycidyl chitosan （GC） with water solubility and organo solubility was first synthesized by reaction of glycidol with chitosan. In order to impart photo-triggered disassembly functionality to GC, 7-diethylamino-4-（hydroxymethyl） coumarin was succinylated and introduced to the side chains of GC. The structure of the resultant chitosan derivative （SCGC） was characterized by FT-IR and 1H-NMR. The photo-sensitivity of SCGC was studied by monitoring the changes in the diameter and Zeta potential of the micelles with UV irradiation. Results showed that SCGC could self-assemble into micelles, and critical aggregation concentration （CAC） of the micelles was 0.07 mg/mL. UV irradiation led to the increase in both the size and negative charges of the micelles surfaces.

关 键 词：香豆素衍生物 光响应 壳聚糖 胶束 

分 类 号：O63[理学—高分子化学]