水介质中药物-AOT混合物的温度依赖的混合胶束化行为(英文)  

Temperature Dependant Mixed Micellization Behavior of a Drug-AOT Mixture in an Aqueous Medium

作　　者：RUB Malik Abdul ASIRI Abdullah M KUMAR Dileep AZUM Naved KHAN Farah 

机构地区：[1]Chemistry Department, King Abdulaziz University [2]Center of Excellence for Advanced Materials Research, King Abdulaziz University [3]Department of Chemistry, Aligarh Muslim University

出　　处：《物理化学学报》2014年第4期699-707,共9页Acta Physico-Chimica Sinica

基　　金：supported by the Chemistry Department and Centre of Excellence for Advanced Materials Research,King Abdulaziz University,Jeddah,Saudi Arabia

摘　　要：The mixed micellization behavior of an amphiphilic antidepressant drug amitriptyline hydrochloride(AMT)in the presence of the conventional anionic surfactant sodium bis(2-ethylhexyl)sulfosuccinate(AOT)was studied at five different temperatures and compositions by the conductometric technique.The critical micelle concentration(cmc)and critical micelle concentration at the ideal state(cmcid)values show mixed micelle formation between the components(i.e.,drug and AOT).The micellar mole fractions of the AOT(X1)values calculated using the Rubingh,Motomura,and Rodenas models show a higher contribution of AOT in the mixed micelles.The interaction parameter(β)is negative at all temperatures and the compositions show attractive interactions between the components.The activity coefficients(f1and f2)calculated using the different proposed models are always less than unity indicating non-ideality in the systems.TheΔGmΘ values were found to be negative for all the binary mixed systems.However,ΔHmΘ values for the pure drug as well as the drug-AOT mixed systems are negative at lower temperatures(293.15-303.15 K)and positive at higher temperatures(308.15 K and above).TheΔSmΘ values are positive at all temperatures but their magnitude was higher at T=308.15 K and above.The excess free energy of mixing(ΔGex)determined using the different proposed models also explains the stability of the mixed micelles compared to the pure drug(AMT)and surfactant micelles.The mixed micellization behavior of an amphiphilic antidepressant drug amitriptyline hydrochloride （AMT） in the presence of the conventional anionic surfactant sodium bis（2-ethylhexyl） sulfosuccinate （AOT） was studied at five different temperatures and compositions by the conductometric technique. The critical micelle concentration （cmc） and critical micelle concentration at the ideal state （cmcid） values show mixed micelle formation between the components （i.e., drug and AOT）. The micellar mole fractions of the AOT （X1） values calculated using the Rubingh, Motomura, and Rodenas models show a higher contribution of AOT in the mixed micelles. The interaction parameter （β） is negative at all temperatures and the compositions show attractive interactions between the components. The activity coefficients （f1 and f2） calculated using the different proposed models are always less than unity indicating non-ideality in the systems. The AGm values were found to be negative for all the binary mixed systems. However, △Hme values for the pure drug as well as the drug-AOT mixed systems are negative at lower temperatures （293.15-303.15 K） and positive at higher temperatures （308.15 K and above）. The △Sme values are positive at all temperatures but their magnitude was higher at -308.15 K and above. The excess free energy of mixing （△Gex） determined using the different proposed models also explains the stability of the mixed micelles compared to the pure drug （AMT） and surfactant micelles.

关 键 词：抗抑郁药物 临床分析 药物治疗 浓度 

分 类 号：TQ460.1[化学工程—制药化工]