动脉粥样硬化炎症机制及阿托伐他汀药物多样性的研究进展  

Developments in Inflammation Mechanism of Atherosclerosis and Pleiotropic Effects of Atorvastatin

作　　者：胡小菁 迟丽屹[2] 张文韬 段宁 冯占斌 

机构地区：[1]西安市第九医院心血管内科,陕西西安710054 [2]解放军451医院神经内科,陕西西安710054 [3]西安市红会医院,陕西西安710054

出　　处：《心血管病学进展》2014年第2期261-265,共5页Advances in Cardiovascular Diseases

基　　金：兰州军区医药卫生科研计划项目(编号:CLZ12JA24);陕西省自然科学基础研究计划项目(编号:2012JM4004)

摘　　要：近年研究显示,动脉粥样硬化是一种慢性炎症。炎症在动脉粥样硬化的发生、发展和演变过程中起着重要作用。他汀类药物是治疗高脂血症及预防动脉粥样硬化性疾病的基石。已有大量研究证实,他汀类药物通过降脂作用改善心血管疾病的预后,而且还通过抗炎、改善内皮功能、抗血小板活性、稳定斑块等作用使患者获益,即他汀类药物有多效性。现就具有代表性的阿托伐他汀,对他汀类药物多效性的研究进展进行综述。Recent studies have shown that atherosclerosis is a type of chronic inflammation. Inflammation plays an important role in the occurrence, development and evolution of atheroselerosis. Statins have an established role in the treatment of hypercholesterolemia and the prophylactic treatment of patients with atherosclerotic disease. It has been shown that statins can improve the outcomes of cardiovascular disease not only through their lipid-lowering function, but also the antiplatelet and stabilization of plaques, all of which are＂ pleiotropic effects＂. This review examines the role of atorvastatin and the pleiotropie effects of statins.

关 键 词：动脉粥样硬化 炎症 阿托伐他汀 多效性 

分 类 号：R543.5[医药卫生—心血管疾病]