碳青霉烯酶基因型的研究进展  

Progess about carbapenemase genotypes

作　　者：杨莉[1] 张红岩[1] 

机构地区：[1]滨州市人民医院检验科,山东滨州256610

出　　处：《中国微生态学杂志》2014年第3期366-368,共3页Chinese Journal of Microecology

摘　　要：碳青霉烯类抗菌药物具有广泛的抗菌活性,是治疗革兰阴性杆菌感染的一线药物。随着应用的增加,耐药性的问题日益严重。碳青霉烯酶是目前发现肠杆菌科细菌对碳青霉烯类抗菌药物耐药的主要机制。准确快速检测这些耐药基因是控制其传播的关键。本研究对碳青霉烯酶基因型的研究进展进行综述。Carbapenem is a new β-1actam antibiotic w ith broad anhmmroblal spectrum and resistance to β-1acta- mase hydrolysis, which has been the first choice to treat gram negtive bacillus. With the increase of application, the resistance is more serious. Carbapenem takes part in the major mechanism of carbapenem resistance in enter- obacteriaceae. It is important to accurate these resistance genes in controlling their spread. In this article, the re- search progress about carbapenemase genetype which was reviewed.

关 键 词：碳青霉烯酶 基因型 耐药性 

分 类 号：R378.992[医药卫生—病原生物学]