毛细支气管炎患儿血清NT-proBNP变化意义  

Significance of change of serum NT-proBNP in children with capillary bronchitis

作　　者：汪玉堂[1] 张月霞[2] 韦祁山[2] 

机构地区：[1]西北民族大学医学院,甘肃兰州730030 [2]兰州市妇幼保健院儿科

出　　处：《中国妇幼保健》2014年第11期1694-1696,共3页Maternal and Child Health Care of China

基　　金：兰州市科技计划项目〔2012-1-15〕;西北民族大学校级科研团队项目〔xbmucxtd-2011-1〕

摘　　要：目的:通过观察毛细支气管炎患儿血清NT-proBNP水平变化,评估其临床价值。方法:对46例毛细支气管炎住院患儿于急性期及恢复期检测血清NT-proBNP水平,并对检测结果进行分析。结果:毛细支气管炎急性期血清NT-proBNP水平显著高于对照组及恢复期(均P=0.000),急性期血清NT-proBNP阳性率高于恢复期(P=0.020),恢复期NT-proBNP水平高于对照组(P=0.000);毛细支气管炎急性期血清NT-proBNP与CRP呈直线正相关(r=0.921,P=0.000)。结论:毛细支气管炎患儿存在一过性心肌损伤,感染越重,NT-proBNP水平越高。恢复期患儿也有较高的血清NT-proBNP水平,提示临床症状好转但心肌损害仍可持续较长时间。Objective： To evaluate the clinical value of N - terminal pro - brain natriuretic peptide （ NT - proBNP） by observing the change of serum NT - proBNP level in children with capillary bronchitis. Methods： Serum levels of NT - proBNP were detected in 46 children with capillary bronchitis at acute phase and recovery phase respectively, and the results were analyzed. Results： Serum level of NT - proBNP in capillary bronchitis group at acute phase was statistically significantly higher than those in control group and capillary bron- chitis group at recovery phase （all P = 0. 000） . The positive rate of serum NT - proBNP at acute phase was statistically significantly higher than that at recovery phase in capillary bronchitis group （ P = 0. 020）, serum level of NT - proBNP at recovery phase in capillary bronchitis group was statistically significantly higher than that in control group （ P = 0. 000） ; at acute phase in capillary bronchitis group, there was a linear positive correlation between serum NT- proBNP and CRP （r = 0. 921, P = 0. 000） . Conclusion： Transient myocardial damage exists in the children with capillary bronchitis, the severer infection is, the higher serum NT - proBNP level is ; serum NT - proBNP level is high in children with capillary bronchitis at recovery phase, which indicates that myocardial damage may exist for a long time though the clinical symptoms are improved.

关 键 词：氨基末端脑利钠肽前体 C反应蛋白 毛细支气管炎 心肌损害 儿童 

分 类 号：R725.6[医药卫生—儿科]