化妆品中酞酸酯物质测定及女性人群暴露评估  

Determination of phthalic acid esters in cosmetics and general female population exposure assessment

作　　者：王力强[1,2] 李荔群[1] 吴岷[1] 厉曙光 

机构地区：[1]复旦大学公共卫生学院营养与食品卫生教研室教育部公共卫生安全重点实验室,上海200032 [2]上海健康职业技术学院

出　　处：《中国公共卫生》2014年第4期478-481,共4页Chinese Journal of Public Health

基　　金：国家自然科学基金(81172673)

摘　　要：目的检测化妆品中3种酞酸酯类化合物(phthalic acid esters,PAEs)的含量,并结合化妆品使用情况调查,对一般女性人群通过化妆品接触的PAEs进行暴露评估。方法采用气相色谱-质谱法检测上海市某化妆品连锁商店和某大型超市采集的护肤品、香水、美发产品和指甲油等55个化妆品样品中邻苯二甲酸二乙酯(DEP)、邻苯二甲酸二丁酯(DBP)和邻苯二甲酸二异辛酯(DEHP)3种PAEs类物质在55个样品中的含量;通过问卷调查某大城市一般女性人群的化妆品使用情况,并对其通过化妆品接触的PAEs进行暴露评估。结果 55个化妆品样品中DEP、DBP和DEHP检出率分别为40.0%、83.6%和87.8%,平均检出浓度分别为3.775、0.043和0.059μg/mL;结合使用情况评估一般女性人群经化妆品对DEP、DBP和DEHP 3种PAEs的日均暴露量分别为DEP 0.815μg/d、DBP3.117μg/d和DEHP 1.049μg/d。结论化妆品中DEP、DBP、DEHP 3种PAEs检出率较高,但检出量较低,一般女性人群经化妆品对3种PAEs的暴露量均远低于目前制定的暴露量上限。Objective To detect concentrations of three types of phthalic acid esters（PAEs）in cosmetics and to assess daily exposure to PAEs in general female population with a survey on cosmetics use-patterns.Methods Three types of PAEs in 55 cosmetic samples,which were collected from a cosmetics chain stores and a large supermarket in Shanghai including skin care products,perfumes,hair products and nail polish,were detected with gas chromatography-mass spectrometry（GC-MS）.Use-patterns of cosmetics in general female population from a metropolis were surveyed with a questionnaire.Results Detection rates of diethyl-o-phthalate（DEP）,di-n-butyl phthalate（DBP）and di-（2-ethylhexyl）phthalate（DEHP）were 40%,83.6% and 87.8% and the average concentrations were 3.775 μg/mL,0.043 μg/mL and 0.059 μg/mL,respectively.Combined with the results of the survey on use-patterns,the daily exposure to the three kinds of PAEs were 0.815 μg/d（DEP）,3.117 μg/d（DBP）and 1.049 μg/d（DEHP）through the use of cosmetics.Conclusion The detection rates of three types PAEs in cosmetics are high but the concentrations of the PAEs are low.The general female population＇s daily exposure to three types PAEs through cosmetics is very low,and much lower than current exposure limits.

关 键 词：酞酸酯类化合物(PAEs) 邻苯二甲酸二乙酯(DEP) 邻苯二甲酸二丁酯(DBP) 邻苯二甲酸二异辛酯(DEHP) 化妆品 暴露评估 

分 类 号：R181.2[医药卫生—流行病学]