耳甲部电针刺激对肥胖大鼠摄食和脂肪代谢的影响  

Effect of electro-acupuncture(EA) stimulation of auricular concha region(ACR) on dietary-induce obesity in Rats

作　　者：冉红星 唐青青[1] 王茵萍[1] 

机构地区：[1]南京医科大学第一附属医院针灸科,南京210029

出　　处：《中国中医基础医学杂志》2014年第3期372-374,396,共4页JOURNAL OF BASIC CHINESE MEDICINE

基　　金：江苏省中医药领军人才培养计划(LJ200919)

摘　　要：目的:观察耳甲部电针刺激对肥胖鼠体质量、摄食、脂肪代谢的影响。方法:60只4周SD雄性大鼠独笼饲养,按随机数字表法抽取10只作为空白对照组(Normal组)正常食物喂养,余50只高脂食物喂养8周后,36只大鼠体质量高于空白对照组体质量平均数的10%,将其按随机数字表法分成模型组(Model组)、耳甲部电针刺激组(EA-ACR组)、非耳甲部电针刺激组(ShamEA-ACR组),每组12只。观察肥胖大鼠的体质量、摄食量、胃排空、内脏脂肪质量和棕色脂肪质量的变化。结果:与Model组比较,EA-ACR组大鼠体质量明显下降(P=0.02),睾周脂肪减少(P=0.02),棕色脂肪含量增多(P<0.05),肾周脂肪差异无统计学意义(P=0.31);Sham-EA-ACR组大鼠体质量下降不明显(P=0.65),睾周脂肪减少不明显(P=0.47),棕色脂肪含量变化差异无统计学意义(P>0.05),肾周脂肪差异无统计学意义(P=0.30);摄食量高脂饲料各组明显低于空白对照组(P<0.05),高脂饲料各组差异无统计学意义(P>0.05);胃排空各组差异无统计学意义(P>0.05);与Sham-EA-ACR组比较,EA-ACR组大鼠体质量下降有意义(P<0.05),睾周脂肪减少(P=0.01),肾周脂肪减少(P<0.05),棕色脂肪含量增多(P<0.05)。结论:耳甲部电针刺激可能主要是通过促进脂肪代谢产生减肥的效果。Objective ：To assess the effects of electro-acupuncture （EA） stimulation of auricular concha region （ACR） on the body weight ,food intake and fat metabolism in obesity rats. Methods ：60 4 weeks SD male rats were housed in alone cages, randomly selected 10 as blank control group with normal breeding; than 50 feed with high-fat food for 8 weeks,36 building successful rats were randomly divided into model group,electro-acupuncture （EA） stimulation of auricular coneha region （EA-ACR） group, shame electro-acupuncture （EA） stimulation of auricular concha region （sham-EA-ACR） group, n = 12 . Observe the change of obese rats weight, food intake , gastric emptying , visceral fat weight and brown fat weight . Results ： compared with model group, EA-ACR group rats weight loss （ P = 0.02 ） , epididymal fat reduction （ P = 0.02） ,brown fat content increased （ P 〈 0.05 ）, No statistical difference in perirenal fat（ P = 0.31 ） ; Sham-EA-ACR group rats weight no significant decline （ P = 0.65 ） , epididymal fat reduction is not obvious （ P = 0.47 ） , brown fat content in statistics no difference （ P 〉 0.05） , no statistical difference in perirenal fat （ P = 0.30） ; high-fat food intake of each group was significantly lower than the normal group （ P 〈 0. 05 ） , no difference in high-fat food intake groups （ P 〉 0.05 ） ; gastric emptying was no significant difference over the groups. Compared with Sham-EA-ACR group, EA-ACR group rats weight loss （ P 〈 0. 05 ） , epididymal fat reduction （ P = 0. 01 ）, perirenal fat reduction （ P 〈 0. 05 ） , brown fat content increased （ P 〈 O. 05 ）. Conclusion： electro-acupuncture （EA） stimulation of auricular concha region （ACR） can produce weight loss, and its mechanism may be mainly through the promotion of fat metabolism.

关 键 词：耳甲部 电针 肥胖 脂肪代谢 

分 类 号：R245[医药卫生—针灸推拿学]