家蚕对2型糖尿病大鼠氧化应激水平的影响  

Impacts of Silkworm on the Level of Oxidative Stress in the Rats of Type 2 Diabetes

作　　者：黄亦琦[1] 康小红[1] 王梅兰[1] 杨辉[1] 庄媛[1] 罗友华[1] 许光辉[1] 黄恺飞[1] 

机构地区：[1]厦门市医药研究所,福建厦门361008

出　　处：《世界中西医结合杂志》2014年第3期245-247,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：福建省自然科学基金项目(No.2011D006);厦门市科技计划项目(No.20124040)

摘　　要：目的观察家蚕对2型糖尿病大鼠氧化应激水平的影响,探讨其对糖尿病的作用机制。方法以高热量饮食喂养SD大鼠6周加小剂量链脲佐菌素(STZ)建立2型糖尿病大鼠模型,并随机分为模型对照组、吡格列酮组、家蚕高、中、低剂量组,共5组,给药4周后测定大鼠血液中超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)、一氧化氮合成酶(NOS)水平。结果与模型组相比,家蚕各剂量组均可显著升高2型糖尿病大鼠模型血清SOD水平(P<0.01),家蚕中、低剂量组可不同程度的降低血清MDA、NO、NOS的含量(P<0.05)。结论家蚕可提高2型糖尿病大鼠抗氧化能力,为家蚕的临床应用提供了实验依据。Objective To observe the impacts of silkworm on oxidative stress level in the rats of type 2 diabetes and explore its effect mechanism on diabetes.Methods The high-energy food was used to feed SD rats for 6 weeks together with low-dose streptozotocin（STZ）so as to prepare the rat models of type 2 diabetes.Five groups were divided randomly,such as control group,Popglitazone group,high-dose silk-worm group,middle-dose silkworm group and low-dose silkworm group.After medication for 4 weeks,the levels of SOD,MDA,NO and NOS were determined in blood.Results Compared with the model group,SOD level was increased significantly in the rat models of type 2 diabetes of each dose group（P〈0.01 ）.The lev-els of MDA,NO and NOS were reduced in the middle-dose and low-dose groups to different extents（P〈0.05）.Conclusion Silkworm improves the oxidation resistance in the rats of type 2 diabetes,which pro-vides the experimental evidences on the clinical application of silkworm.

关 键 词：家蚕 2型糖尿病 氧化应激 

分 类 号：R282.7[医药卫生—中药学] R587.1[医药卫生—中医学]