蛇床子素微乳的制备及其理化性质研究  

Study of the Preparation and Physiochemical Properties of Osthole Microemulsion

作　　者：王永辉[1] 房树标[1] 高丽[1] 王洋[1] 周然[1] 

机构地区：[1]山西中医学院,山西太原030024

出　　处：《世界中西医结合杂志》2014年第3期257-259,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：山西省科技创新项目(2008101017);山西省科技基础条件平台建设项目(2011091014)

摘　　要：目的研究制备蛇床子素微乳,并对其理化性质进行考察。方法以油酸乙酯、肉豆蔻酸异丙酯(IPM)、角鲨烷为油相,以Tween-80、PEG-40氢化蓖麻油(PEG-40)、乙氧基化加氢羊毛脂为表面活性剂,以无水乙醇、1,2-丙二醇、丙三醇为助表面活性剂,通过伪三元相图的绘制对微乳组分进行筛选确定;并以微乳外观、粒径及其分布、黏度、电导率、电位、折光率等为指标,初步考察蛇床子素微乳的理化性质。结果蛇床子素微乳的处方组合为:IPM∶水∶PEG-40∶1,2-丙二醇:蛇床子素的质量比为1∶1.8∶2.3∶6.9∶0.1。蛇床子素微乳为澄清透明,有蓝色乳光的液体,10 000 r·min-1离心10 min后无分层、浑浊现象,其平均粒径为(55.1±1.3)nm,黏度为(10.3±0.32)mm2·s-1,电导率为(124±0.16)μs·cm-1,电位为(-0.54±0.002)mv,折光率为(1.537 3±0.000 2)。结论蛇床子素微乳理化性质稳定,有望成为蛇床子素的一种新型给药制剂。Objective To study the preparation of osthole microemulsion and investigate its physio-chemical properties.Methods Ethyl oleate,IPM and squalane were taken as oil phase.Tween-80,PEG-40 and ethoxylated lanolin were taken as surfactants.Absolute ethyl alcohol,1 ,2-propylene glycol and glyc-erol were as cosurfactants.Pseudo-ternary phase diagram was used to screen and determine microemulsion components.The appearance,particle size and viscosity of microemulsion,electrical conductivity,potential and refractive index were taken as the indicators to investigate preliminarily the physiochemical properties of osthole microemulsion.Results The recipe of osthole microemulsion：IPM∶water∶PEG-40∶1 ,2-propylene glycol：mass of osthole microemulsion were 1∶1 .8∶2.3∶6.9∶0.1 .Osthole microemulsion was clear and trans-parent and was blue opalescence liquid.The layering and turbidity were not presented after centrifugation at 10 000 r·min^-1 for10min.The mean particle size：55.1 ±1.3 nm,the viscosity：10.3 ±0.32 mm^-2·s-1, electrical conductivity：1 24 ±0.1 6 μs·cm^-1 ,potential：-0.54 ±0.002 mv and refractive index：1 .537 3 ± 0.000 2.Conclusion Osthole microemulsion is stable in physiochemical properties and expected to be the new preparation of osthole.

关 键 词：蛇床子素 微乳 伪三元相图 理化性质 

分 类 号：R284.1[医药卫生—中药学]