藏药莪达夏醇提物对大鼠心肌缺血-再灌注损伤的保护作用  

The Antioxidative Effect of Oxytropis falcata Bunge Ethanol Extract on Rats' Hearts Against Myocardial Ischemia and Reperfushon Injury

作　　者：李振[1] 刘明成[2] 李福安[1] 任世存[1] 马建滨[3] 张得钧[1,2] 

机构地区：[1]青海大学医学院,西宁810001 [2]青海大学生态环境工程学院,西宁810016 [3]青海师范大学生命与地理学院,西宁810008

出　　处：《天然产物研究与开发》2014年第3期423-426,373,共5页Natural Product Research and Development

基　　金：青海省科技厅项目(2011-Z-704);教育部"春晖计划"项目(Z2011021)

摘　　要：本实验探讨藏药莪达夏对大鼠急性心肌缺血再灌注损伤的抗氧化保护作用。采用结扎大鼠冠脉左前降支方法造成心肌缺血再灌注模型,测定再灌注40 min后血清中乳酸脱氢酶(LDH)、肌酸激酶(CK)、超氧化物歧化酶(SOD)、谷肤甘肤过氧化物酶(GSH-Px)活性以及MDA含量。实验结果显示莪达夏可以显著降低心肌缺血再灌注后血清CK、LDH和MDA含量,升高血清SOD和GSH-Px活力(P<0.01,P<0.05)。表明藏药莪达夏对缺血-再灌注心肌损伤有抗氧化保护作用。The article studied the Antioxidant protection of Oxytropisfalcata Bunge Ethanol extract, during acute myocardial ischemia-reperfusion in rats. The model of myocardial ischemia/reperfusion injury in rats was employed by ligating theartery of left anterior descending （LAD）. After the following reperfusion for 40 minutes, the enzyme activity of CK, LDH, SOD ,GSH-Px and the concentration of MDA in rats＇ serum were tested. The results showed that the ethanol of O. falcata Bunge can decrease the enzymatic activity of CK, LDH and the concentration of MDA, and can heighten the enzymatic activity of SOD and GSH-Px （P 〈0.01 ,P 〈0.05） as propranolol can. O.falcata Bunge,has the antioxidant protection effects during acute myocardial ischemia/reperfusion in rats in vivo.

关 键 词：莪达夏醇提物 心肌缺血-再灌注损伤 抗氧化 

分 类 号：R285.5[医药卫生—中药学]