传统药对附子-炮姜的配伍研究  

Study on the Compatibility of Traditional Herbs Couple about Aconitum carmichaelii and Zingiber officinale Preparata

作　　者：叶强[1] 付昆[2] 彭成[1] 郭力[1] 

机构地区：[1]成都中医药大学药学院,成都610072 [2]成都市第三人民医院,成都610031

出　　处：《中国药房》2014年第15期1395-1398,共4页China Pharmacy

基　　金：四川省教育厅科研项目(No.11ZA066);四川省教育厅中国盐文化研究中心项目(No.YWHY13-01)

摘　　要：目的:以附子、炮姜为对象,研究温热药对配伍前后关键组分的变化,探讨传统药对附子-炮姜配伍的科学意义。方法:采用紫外分光光度法测定附子总生物碱、酯型生物碱含量在配伍前后的变化,结合高效液相色谱指纹图谱研究附子与炮姜配伍前后附子总体成分的变化。结果:附子与炮姜配伍后,附子总生物碱与酯型生物碱含量均大幅减少;从指纹图谱分析可知,附子与炮姜配伍后,附子各成分总加权变化率为81.00%,即总体上附子成分有所减少,为配伍前的81.00%。结论:附子与炮姜配伍后抑制了附子的热性,增强了炮姜的温性,主要用于温经止血。OBJECTIVE： To investigate the significance of the compatibility of traditional herbs couple via studying the changes of key components before and after compatibility of warm-hot herbs couple about Aconitum carmichaelii and Zingiber officinale Preparata. METHODS ： UV spectrophotometry was adopted to determine the contents of total alkaloid and ester alkaloids before and after compatibility; HPLC fingerprinting was used to study the main components of A. carmichaelii before and after compatibility. RESULTS： The contents of total alkaloids and ester alkaloids were reduced greatly after compatibility; the fingerprint indicated the percentage of weighting change in each component of A, carmichaelii was 81.00% after compatibility, in other words, the compo- nent ofA. carmichaelii decreased to some extent after compatibility and was 81.00% of previous component. CONCLUSIONS： The compatibility ofA. carmichaelii and Z. officinale Preparata suppress hot property ofA. carmichaelii, but enhance the warm property of Z. officinale Preparata, which is mainly used for warming meridian to stop bleeding.

关 键 词：附子 炮姜 配伍 总生物碱 酯型生物碱 高效液相色谱指纹图谱 

分 类 号：R284.1[医药卫生—中药学] R917[医药卫生—中医学]