60例骨瓜提取物注射剂不良反应文献分析  

Literature Analysis of 60 Cases of ADR Induced by Gugua Extract Injection

作　　者：蔡志琴[1] 周福永[1] 陈晨[1] 

机构地区：[1]浙江省台州医院,浙江临海317000

出　　处：《中国药房》2014年第15期1419-1421,共3页China Pharmacy

摘　　要：目的：探讨骨瓜提取物注射剂致不良反应（ADR）发生的一般规律及特点，为临床合理用药提供参考。方法：检索中国期刊全文数据库、维普数据库、万方数据库2003—2013年收录的骨瓜提取物注射剂致ADR的相关文献，对纳入文献的ADR病例的一般情况、给药方法、ADR发生时间、累及系统和／或器官及转归等进行分类、归纳、总结。结果：符合入选条件的病例报道共60例。骨瓜提取物注射剂所致ADR多集中于男性、40-49岁患者中；63．33％的病例ADR在用药30min内发生，为速发型过敏反应：经停药及对症治疗后全部病例预后良好。结论：在合理使用骨瓜提取物注射剂的同时，应加强用药监测与预防，以尽量减少或避免ADR的发生。OBJECTIVE： To investigate the regularity and characteristics of ADR induced by Gugua extract injection, and to provide guidance for rational drug use in the clinic. METHODS： Retrieved from CNKI, VIP and Wanfang database, related litera- tures about ADR induced by Gugua extract injection from 200a to 2013 were included, and classified and summarized in respects of general information of patients, route of administration, occurrence time of ADR, systems or organs involved in ADR, out- comes, etc. RESULTS： A total of 60 cases were included, among which most of ADR cases occurred in male aged 40-49 year-old; 63.33% （38 cases） occurred within 30 min and were immediate hypersensitivity. All the symptoms disappeared by termi- nating drug administration and receiving symptomatic treatment. CONCLUSIONS： To decrease or avoid the occurrence of ADR, great importance should be attached to not only rational use of Gugua extract injection, but also monitoring and prevention.

关 键 词：骨瓜提取物注射剂 不良反应 合理用药 

分 类 号：R969.3[医药卫生—药理学] R283.611[医药卫生—药学]