阿维菌素-羟丙基-β-环糊精包合物的制备  

Peparation of avermectin/hydroxypropyl-β-cyclodextrin inclusion compound

作　　者：李运涛[1] 郭宁[1] 沈文[2] 

机构地区：[1]陕西科技大学化学与化工学院,陕西西安710021 [2]陕西科技大学生命科学与工程学院,陕西西安710021

出　　处：《陕西师范大学学报（自然科学版）》2014年第2期50-54,共5页Journal of Shaanxi Normal University：Natural Science Edition

基　　金：国家自然科学基金资助项目(21144008);陕西省自然科学基金资助项目(2011JM2005)

摘　　要：对羟丙基-β-环糊精包合阿维菌素进行了研究.通过应用溶液搅拌法制取包合物,采用单因素试验和正交试验确定的最佳工艺条件为:主客体投料质量比为100∶3,包合温度为50℃,包合时间为8h.在最佳工艺条件下,用HPLC法确定包合率为39.6%,用称重法确定收率为81.1%,并对包合物做了TG分析.结果表明:被包合后的阿维菌素的水溶性、光稳定性显著提高,同时提高了阿维菌素杀虫杀螨的长效性.Avermectin entrapped in HP-β-cyclodextrin was investigated.The water was selected as medium to prepare the inclusion compound.Employing single factor and orthogonal tests,the best conditions of inclusion process were determined as follows：the feeding quality ratio being 100 ∶ 3,inclusion temperature at 50 ℃,inclusion time for 8 h.Under these conditions,it was determined by HPLC that the inclusion efficiency was 39.6%,and the yield was 81.1%.The inclusion compound was analysed by TG.The results show that the light stability and solubility in water of avermectin entrapped in HP-β-cyclodextrin increase significantly compared with avermectin.The long-term performance of avermectin＇s insecticidal and acaricidal properties are improved significantly.

关 键 词：阿维菌素 HP-β-环糊精 包合 

分 类 号：O69[理学—化学]