固本平喘胶囊对哮喘大鼠血清MDA、SOD、TNF-α影响的实验研究  

Experimental Study on Effects of Guben Pingchuan Capsule on Serum MDA,SOD,TNF-α in Asthma Rats

作　　者：陈梅玲[1] 陈夏静[1] 李果[1] 

机构地区：[1]深圳市罗湖区人民医院,深圳518001

出　　处：《中国中医药科技》2014年第2期147-148,共2页Chinese Journal of Traditional Medical Science and Technology

摘　　要：目的:通过观察固本平喘胶囊对哮喘大鼠血清中丙二醛(MDA)、超氧化物歧化酶(SOD)及肿瘤坏死因子-α(TNF-α)的影响,探讨该方防治支气管哮喘的作用机制。方法 :取SD雄性大鼠70只,随机分为7组,正常组、模型组、西药对照组、中药对照组及固本平喘胶囊高、中、低剂量组,每组10只,分组给药22天后测定大鼠血浆中MDA、SOD及TNF-α的含量。结果:固本平喘胶囊各防治组的MDA含量减少;SOD活性升高;TNF-α水平降低,与模型组比较,均有显著性差异;与阳性组比较,无显著性差异(P>0.05)。结论:固本平喘胶囊可通过抑制炎性介质及抗氧化作用防治哮喘。Objective：To discuss the mechanism of Guben pingchuan capsule in prevention and cure of bronchial asthma by observing the effects of the capsule on MDA,SOD and TNF-α in serum of rats with asthma.Methods：seventy SD male rats were randomly divided into 7 groups with 10 rats in each group：normal group,model group,western medicine control group,Chinese medicine control group,high,middle,low dosage of Guben pingchuan capsule groups.The levels of MDA,SOD and TNF-α in serum were tested after 22 days of treatment on all groups.Results：The content of MDA in Guben pingchuan capsule groups reduced; activity of SOD increased; level of TNF-α decreased,there were significant difference to compared with model group on above three indexes; there was no significant difference to compared with Chinese medicine control group and western medicine control group （P ＜0.01）.Conclusions：Guben pingchuan capsule could prevent and cure asthma by inhibiting inflammation mediators and anti-oxygenation.

关 键 词：哮喘 固本平喘胶囊 丙二醛 超氧化物歧化酶 肿瘤坏死因子 大鼠 

分 类 号：R285.5[医药卫生—中药学]