二甲双胍对合并2型糖尿病慢性心力衰竭患者的疗效观察  

Study on effect of metformin on patients with chronic heart failure complicated with type 2 diabetes

作　　者：吕飞娟[1] 杜曙光 杨燕玲[1] 江辉[1] 

机构地区：[1]解放军第113医院内分泌科 [2]东海舰队门诊部,浙江宁波315040

出　　处：《临床军医杂志》2014年第3期230-232,共3页Clinical Journal of Medical Officers

摘　　要：目的观察二甲双胍对合并2型糖尿病慢性心力衰竭患者的疗效。方法回顾性分析合并2型糖尿病的慢性心力衰竭患者服用二甲双胍组(试验组)和未服用二甲双胍组(对照组)的心功能改善情况,比较服用1年后两组治疗前后的心衰量表积分、体质量、NYHA分级、左室射血分数、血浆BNP等指标。结果与对照组比较,试验组在连续服用1年后,体质量下降(P<0.05),心衰量表积分改善(P<0.05),血浆BNP下降(P<0.05),但左室射血分数无显著改变(P>0.05)。结论对于合并2型糖尿病的慢性心力衰竭患者,使用二甲双胍可减轻患者体质量,在一定程度上有助于改善患者心衰症状,且不增加乳酸性酸中毒发生。Objective To explore the effect of metformin on the patients with chronic heart failure （CHF） complicated with type 2 diabetes. Methods Retrospective analysis was carried out on diabetic CHF patients, who were divided into metformin group （in which the patients had taken the drug for one year） and non-metformin group. The two groups were compared in the aspects of such indicators as heart failure scale, body mass, NYHA class, left ventricular ejection fraction and plasma BNP. Results Compared with the non-metformin group, the metformin group had a decrease in body mass （ P 〈0. 05 ） , an improvement in heart failure scale （ P 〈 0.05 ） and a decrease in plasma BNP（P 〈 0. 05）. There was no change in left ventricular ejection fraction. Conclusion To the patients with CHF complicated with type 2 diabetes, the use of metformin for long-term can reduce the patient＇ s weight and im- prove heart failure, without increasing the incidence of lactic acidosis.

关 键 词：二甲双胍 2型糖尿病 慢性心力衰竭 

分 类 号：R587.1[医药卫生—内分泌]