EGFR靶向的PET/SPECT分子成像研究进展  

Progress of EGFR-Targeted PET/SPECT Molecular Imaging

作　　者：孙莹莹[1,2] 孙夕林[1,2] 王凯[1,2] 李宏利 赵周社 申宝忠[1,2] 

机构地区：[1]哈尔滨医科大学附属第四医院放射科,黑龙江哈尔滨150001 [2]黑龙江省高校分子影像重点实验室,黑龙江哈尔滨150001 [3]美国通用电气医疗集团(中国),北京100176

出　　处：《现代生物医学进展》2014年第10期1980-1986,1792,共7页Progress in Modern Biomedicine

基　　金：国家自然科学基金资助项目(81130028;81101088);黑龙江省科技攻关资助项目(重大项目GA12C302);教育部高等学校博士学科点专项科研基金(博导类;201123071100203);中国博士后科学基金资助项目(2012M510095;2013T60388);黑龙江省博士后基金资助项目(LBH-Z12199);黑龙江省教育厅科学技术研究项目(12521184);哈尔滨医科大学伍连德青年科学基金(WLD-QN1119);哈尔滨医科大学附属第四医院杰出青年基金

摘　　要：恶性肿瘤的发病率及死亡率逐年递增,分子靶向治疗为癌症治疗带来了新的革命,表皮生长因子受体(EGFR)在癌症发生、发展中发挥重要作用,针对EGFR的分子靶向治疗已成为近年研究热点。目前,已有多种EGFR分子靶向药物应用于临床,但总体有效率偏低。研究表明EGFR过表达和/或突变对治疗效果影响显著,因此治疗前准确评价肿瘤EGFR表达水平及突变状态显得尤为重要。分子成像能够实现活体细胞及分子水平生物学过程成像,并进行定性定量研究,使在体揭示EGFR表达状态成为可能。本文简述EGFR靶向分子成像的研究进展并对不同分子探针成像结果进行比较分析,对不同分子成像探针的功能进行评价,以期有益于EGFR靶向分子成像探针的研发及EGFR靶向分子成像研究。The morbidity and mortality of cancer has been increasing year by year.Molecular targeted therapy has brought a new revolution for cancer therapy. Epidermal growth factor receptor （EGFR） plays an key role in the occurrence and development of carcino- ma. So EGFR-targeted therapy has become hotspot in recent years. Currently, there are a variety of EGFR-targeted drugs used clinically, however, the overall efficiency is unsatisfied. Large scale of studies have shown that the overexpression and/or mutation of EGFR affected the efficiency significantly. Therefore, it seems to be particularly important that evaluate the expression level and/or mutation of EGFR in the tumor before treatment accurately. Molecular imaging can achieve the image of the biological processes in cellular and molecular level in vivo, and carry on qualitative and quantitative calculation,which makes it possible that reveal the expression level and/or mutation of EGFR in vivo. This article briefly introduce the progress of EGFR-targeted molecular, imaging,and the imaging and function of different probes. Are compared and analysed, so that can benefit the development of molecular imaging probes and EGFR-targeted molecular imaging researchment.

关 键 词：表皮生长因子受体(EGFR) 分子成像探针 SPECT PET成像 

分 类 号：R814.42[医药卫生—影像医学与核医学] R730[医药卫生—放射医学]