Preparation of polyclonal antibody highly specific for mouse BRD7 protein and its application  

作　　者：Heran Wang Ran Zhao Ming Zhou Chi Guo Yukun Liu Shihe Jiang Xiayu Li Wei Xiong Jian Ma Shuping Peng Xiaoling Li David C. Schmitt Ming Tan Guiyuan Li 

机构地区：[1]Cancer Research Institute, Central South University, Changsha 410078, China [2]Department of Gastroenterology, The Third Xiang-Ya Hospital, Centrai South University, Changsha 410013, China [3]Mitchell Cancer Institute, University of South Alabama, Mobile, AL 36604, USA

出　　处：《Acta Biochimica et Biophysica Sinica》2014年第2期163-166,共4页生物化学与生物物理学报（英文版）

基　　金：This work was supported by grants from the National Natural Science Foundation of China （Nos. 81071686, 81171934, 81328019）, the Programme of Introducing Talents of Discipline to Universities of China （No. 111-2-12）, the Project Sponsored by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry （the 44th）, and the Free Exploration Program of Central South University of China （No. 2013zzts073）,

摘　　要：BRD7 was first identified as a novel bromodomain gene related to nasopharyngeal carcinoma （NPC） [1,2]. Over- expression of BRD7 in NPC cells inhibits cell growth and cell cycle progression from G1 to S phase by transcriptional regulation of important molecules involved in Ras/MEK/ ERK, Rb/E2F, and [3-catenin pathways [3-5]. BRD7 is mainly localized in the nucleus and possesses a functional nuclear localization signal sequence [5]. It has been identi- fied as a subunit of the SWI/SNF chromatin-remodeling complexes and is involved in the regulation of transcription as a transcription factor [6,7].BRD7 was first identified as a novel bromodomain gene related to nasopharyngeal carcinoma （NPC） [1,2]. Over- expression of BRD7 in NPC cells inhibits cell growth and cell cycle progression from G1 to S phase by transcriptional regulation of important molecules involved in Ras/MEK/ ERK, Rb/E2F, and [3-catenin pathways [3-5]. BRD7 is mainly localized in the nucleus and possesses a functional nuclear localization signal sequence [5]. It has been identi- fied as a subunit of the SWI/SNF chromatin-remodeling complexes and is involved in the regulation of transcription as a transcription factor [6,7].

分 类 号：Q786[生物学—分子生物学] TN248.1[电子电信—物理电子学]