泪腺Mikulicz病的MRI表现  

MRI findings of Mikulicz's disease involving the lacrimal gland

作　　者：冯莉莉[1,2] 燕飞[1] 付琳[1] 鲜军舫[1] 麻增林[2] 

机构地区：[1]首都医科大学附属北京同仁医院放射科,100730 [2]北京中医药大学第三附属医院

出　　处：《眼科》2014年第1期47-50,共4页Ophthalmology in China

基　　金：北京市卫生系统高层次卫生技术人才学科骨干(2011-3-047)

摘　　要：目的研究泪腺Mikulicz病的MRI表现。设计回顾性病例系列。研究对象泪腺Mikulicz病患者24例。方法回顾分析24例经病理证实的泪腺Mikulicz病患者的MRI影像资料。所有患者均行常规MRI扫描及增强扫描,其中11例行动态增强扫描。主要指标病变MRI信号特征、累及范围。结果 24例患者中17例(70.8%)双侧泪腺受累,7例单侧泪腺受累,左侧受累5例,右侧受累2例。MRI T1WI呈等-略低信号;T2WI呈略低、等信号或略高信号,增强后中度至明显均匀强化。11例行动态增强扫描,时间-信号强度曲线为持续上升型2例,平台型9例,Tpeak值为(226.4±85.5)s,WR值为5.64%±4.81%。8例(33.3%)可见眼外肌增粗、强化;2例可见眶脂体炎;5例可见额神经增粗、增强;1例可见双侧眶下神经增粗、强化。结论泪腺Mikulicz病的MRI特征为双侧泪腺弥漫性增大;可累及眶脂体、眼外肌、三叉神经分支;MRI能清楚地显示病变的累及范围。(眼科,2014,23:47-50)Objective To evaluate MRI features of Mikulicz＇s disease involving the lacrimal gland. Design Retrospective case se- ries. Participants Twenty-four patients with Mikuliez＇s disease involving the lacrimal gland confirmed by operation and pathology. Methods MRI findings of 24 cases with Mikulicz＇s disease involving the lacrimal gland were retrospectively reviewed. MRI examina- tion and contrast-enhanced imaging were performed in all patients and dynamic contrast-enhanced MRI was performed in 11 patients. Main Outcome Measures The MRI features of the lesion. Results In 24 cases, the lesion invaded bilateral lacrimal gland in 17 cases （70.8%）, and unilateral in 7 cases. In the 7 cases, the lesion located in the left side in 5cases and right side in 2 cases. Compared with the brain gray matter, the lesion showed isointensity or hypointensity on T1WI and iso-, hypo- or hyperintensity on T2WI. After injec- tion of the contrast medium, they showed moderately to significantly enhancement homogeniously. 11 cases who underwent dynamic contrast-enhanced MRI, a gradually enhancing pattern displayed in 2 cases and platform in 9 cases in time intensity curve. Moreover, the ocular muscles, corpus adiposnm orbitae, infraorbital nerve and frontal nerve were involved in 8 cases （33.3%）, 2 cases, 1 case and 5 cases respectively. Conclusion The MRI features of Mikulicz＇s disease involving the lacrimal gland was enlargement of bilateral lacrimal gland diffusedly, and the involvement of trigeminal nerve, extraocular muscles and corpus adiposum orbitae. MRI can show the extent of the lesion clearly.

关 键 词：MIKULICZ病 磁共振成像 泪腺 

分 类 号：R445.2[医药卫生—影像医学与核医学] R777.21[医药卫生—诊断学]