量子点在生物检测中的应用  

Application of Quantum Dots in Biological Detection

作　　者：初丛波 单玉萍[2] 王宏达[2] 

机构地区：[1]吉林省水利水电勘测设计研究院,长春130021 [2]中国科学院长春应用化学研究所电分析化学国家重点实验室,长春130022

出　　处：《应用化学》2014年第4期377-388,共12页Chinese Journal of Applied Chemistry

基　　金：国家自然科学基金资助项目(21303181)~~

摘　　要：过去十几年里,量子点从材料科学到生命科学、从基础研究到实际应用都开展了广泛的研究。量子点在生物成像、光治疗、药物/基因转运、太阳能电池等领域均具有广泛的应用。通过调节量子点的表面性质,实现量子点与细胞相互作用的可控性是一个关键的问题。伴随着量子点潜在毒性问题的产生,纳米毒性成为纳米材料安全性评估的重要指标,并且受到科学家们的高度关注。本文综述了量子点的特性、细胞生物学应用及在生物医药领域相关的细胞毒性研究,并展望了量子点的未来发展趋势。During the past ten years, the application of semiconductor nanocrystal material-quantum dots has displayed an increased tendency in scientific and industrial production fields, and a broad research is developed from materials science to biological applications. The application of quantum dots has substantially impacted on many research areas, such as biological imaging, phototherapy, drug/gene delivery, and solar cell. It is a key point to control the interactions between quantum dots and cell through adjusting surface properties of quantum dots. As the potential cytotoxicity of quantum dots arise, nanotoxicity becomes an important indicator of nanomaterials security assessment, and scientists pay more attention to the research of their potential toxicity. In this review we overviewed the properties of quantum dots, the applications in cell biology and the cytotoxicity research in biomedicine related field. Moreover, the future prospects for applications of quantum dots were briefly presented.

关 键 词：量子点 生物应用 荧光标记 细胞毒性 

分 类 号：O652[理学—分析化学]