神经生长因子眼科给药途径及药代动力学的研究进展  

Research progress on ophthalmological administration routes and pharmacokinetics of nerve growth factor

作　　者：曾爱能[1] 黄丽娜[1] 王凡寅 

机构地区：[1]暨南大学附属深圳市眼科医院,中国广东省深圳市518040

出　　处：《国际眼科杂志》2014年第4期637-640,共4页International Eye Science

摘　　要：神经生长因子是作用于神经系统最重要的生物活性蛋白之一,在眼科临床中应用广泛,给药途径包括全身给药及局部给药。局部给药具有目标性,相对全身给药能更有效的达到必要的眼部浓度且减少了发生副作用的风险,已成为眼科疾病的常见治疗方法。随着给药途径的不断发展,相应的药代动力学研究也受到关注。本综述研究为神经生长因子在眼科局部给药和药代动力学研究提供参考。Nerve growth factor （ NGF ） is one of the most important active protein acting on the nervous system, it is applicated widely in ophthalmology, the administration route includes systemic drug administration and local drug administration. Compared to systemic drug administration, local drug administration is targeted, it is more effective to achieve the necessary concentration in eyes and it reduces the risk of side effects.Local drug administration has been a common treatment method in eye diseases. With the development of administration route, corresponding pharmacokinetic researches have received the concern.This review provides a reference for the study on ophthalmological administration routes and pharmacokinetics of nerve growth factor.

关 键 词：神经生长因子 给药途径 药代动力学 

分 类 号：R96[医药卫生—药理学]