抗突变型瓜氨酸波形蛋白抗体在幼年特发性关节炎中的临床价值  

Clinical Evaluation of Anti-mutated Citrullinated Vimentin Antibody in Juvenile Idiopathic Arthritis

作　　者：刘润荣[1] 李艳青[1] 马秀芬[1] 王晓东[1] 孙希志[1] 

机构地区：[1]潍坊医学院附属医院风湿科,山东潍坊261031

出　　处：《潍坊医学院学报》2014年第1期18-20,共3页Acta Academiae Medicinae Weifang

摘　　要：目的通过检测幼年特发性关节炎(JIA)患者血清中的抗突变型瓜氨酸波形蛋白(MCV)抗体,分析抗MCV抗体与JIA临床表现的关系。方法采用酶联免疫吸附试验(ELISA)检测87例JIA患者和55例非JIA患者的抗MCV抗体,并记录JIA患者的临床指标,分析抗MCV抗体与临床指标的关系。结果 在JIA患者中抗MCV抗体的敏感性和特异性分别为44.8%和98.2%,抗MCV抗体阳性组患者肿胀关节数、压痛关节数和X线关节受累数均明显高于抗MCV抗体阴性组,差异有统计学意义(P<0.05)。结论抗MCV抗体与JIA患者关节受累程度、骨关节侵蚀破坏有关。Objective To detect anti-mutated citrullinated vimentin（MCV} antibody in patients with juven- ile idiopathic arthritis（ JIA } , to evaluate the correlation between anti-MCV antibody and clinical manifestations of JIA. Methods Anti-MCV antibody was detected by enzyme-linked immunosorbent assays { ELISA ） in the serum of 87 JIA patients and 30 patients with other rheumatic diseases and 25 healthy children. The relevance between anti-MCV anti- body and clinical characteristics data was analyzed statistically. Results Anti-MCV antibody had a sensitivity of 44.8% and a specificity of 98.2% in JIA patients. The swollen joint counts, tender joint counts and the number of X-ray involve- ment were significantly higher in anti-MCV positive patients than the anti-MCV negative group （ P 〈 0.05 ）. Conclusion Our data suggest that anti-MCV antibody may be correlated with bone erosion in JIA.

关 键 词：幼年特发性关节炎 抗突变型瓜氨酸波形蛋白抗体 骨关节侵蚀 

分 类 号：R593.2[医药卫生—内科学]