慢性乙型肝炎肝硬化患者血清胆碱酯酶与肝纤维化血清标志物的相关性研究  

Study on the Correlation between the Serum Cholinesterase of Patients with Chronic Hepatitis B Liver Cirrhosis and Hepatic Fibrosis Serum Markers

作　　者：刘甜[1] 李群[2] 谢瑞柱 

机构地区：[1]潍坊医学院传染病学教研室,山东潍坊261053 [2]潍坊医学院附属医院传染科

出　　处：《潍坊医学院学报》2014年第1期39-41,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨慢性乙型肝炎(CHB)和乙肝后肝硬化(LC)患者血清胆碱酯酶(ChE)与肝纤维化标志物透明质酸(HA)、层粘连蛋白(LN)、Ⅳ型胶原(Ⅳ·C)、Ⅲ型前胶原(PCⅢ)的相关性。方法 用CX5型全自动生化分析仪测定143例CHB和134例LC患者血清ChE水平,用放射免疫法(RIA)测定HA,LN,Ⅳ·C,PCⅢ水平,并与92例健康体检者比较。结果 CHB轻度、中度、重度和LC A级、B级、C级患者,随病情进展,血清ChE活性依次降低;肝纤维化指标HA,LN,Ⅳ·C,PCⅢ水平逐渐升高,变化趋势的差异具有显著性(P<0.05);血清ChE活性与HA,LN,Ⅳ·C,PCⅢ水平呈显著负相关。结论血清ChE和HA,LN,Ⅳ·C,PCⅢ水平是反映肝纤维化程度的敏感指标,对该疾病的早期诊断、治疗及预后判断有重要的临床应用价值。Objective To explore the correlation between serum cholinesterase（ChE） of chronic hepatitis {CHB） and liver cirrhosis（LC） patients and liver fibrosis markers, such as hyaluronic acid（HA） ,laminin（LN） , colla- gen type Ⅳ （ IV · C ） , procollagen type m （ PC m ）. Methods The serum ChE was assayed by CX5 automatic biochemi- cal in 143 cases of CHB and 134 cases of LC;the serum HA, LN, Ⅳ· C, PC m were assayed by radioimmunoassay （ RIA）. Then detection results of these markers were compared with those from 50 healthy people. Results Among pa- tients with CHB graded mild,moderate, severe and LC graded, A B C,the serum ChE activity gradually decreased, with the progress of the disease, but hepatic fibrosis indexes of HA, LN, Ⅳ · C, PC m level gradually increased. It showed the statistical difference（P 〈 0.01）. The change trend was negatively correlated between the serum ChE activity and HA, LN, Ⅳ · C,PC m level. Conclusion The change of serum ChE and HA,LN, IV · C,PC m level is a sensitive markers to reflect the degree of hepatic fibrosis. It shows great value of clinical application for the disease early diagnosis, treat- ment and prognosis.

关 键 词：乙型肝炎 慢性 胆碱酯酶 肝硬化 肝纤维化 

分 类 号：R512.6[医药卫生—内科学]