地塞米松热敏性凝胶鼓室内局部治疗大鼠梅尼埃病的研究  

Tympanic Dexamethasone Thermosensitive Gel in the Treatment of Meniere's Disease in Rats

作　　者：王勤[1] 敖华飞[1] 顾健[1] 李聪[1] 

机构地区：[1]上海交通大学医学院附属第三人民医院耳鼻喉-头颈外科,201900

出　　处：《医学研究杂志》2014年第3期54-56,共3页Journal of Medical Research

摘　　要：目的评价地塞米松热敏性凝胶对大鼠自身免疫性梅尼埃病的治疗效果。方法采用泠凝法制备以泊洛沙姆407为基质的地塞米松热敏性凝胶,采用同种粗制内耳抗原免疫大鼠建立自身免疫性大鼠的模型。将诱导自身免疫性梅尼埃病成功的模型动物随机分为3组:生理盐水组(A组),地塞米松溶液组(B组),地塞米松热敏性凝胶组(C组),在用药当天及用药后7、14天分别测定其ABR阈值。结果用药后第7、14天B、C组与A组比较各频率ABR阈值均降低(P<0.05)。用药后第7天频率在16kHz时,C组比B组ABR阈值较低(P<0.05),用药后第14天C组比B组各频率(4kHz、8kHz、16kHz)均较低(P<0.05)。结论地塞米松热敏性凝胶对自身免疫性梅尼埃病的治疗有效果,可以作为临床治疗梅尼埃病的新剂型进行进一步研究。Objective To evaluate the therapeutic effects of dexamethasone thermosensitive gel in treatment of Meniere＇s disease in rats. Methods Dexamethasone thermosensitive gel of poloxamer 407 as the matrix was prepared by the condensation method. Autoim- mune Meniere＇s disease model was established by using the same kind of crude inner ear rats immunized. Then models were randomly di- vided into three groups ： the normal saline group （ A）, dexamethasone solution group （ B）, dexamethasone thermosensitive gel group （C）. The ABR thresholds after treatment of 7, 14 days were measured. Results After treatment of 7, 14 days, compared with group A at each frequency ABR thresholds were lower inn B, C group （P 〈 0.05 ）. On the 7th day after treatment, were lower than B group ABR threshold of the 16kHz frequency （P 〈0.05） of C group. On the 14th day after treatment,each frequency of C group were lower than that of B group （P 〈0.05）. Conclusion Dexamethasone thermosensitive gel was effective for Autoimmune Meniere＇s disease which suggested that it could be used as a new form for treatin~ Autoimmune Meniere＇s disease.

关 键 词：地塞米松 热敏性凝胶 自身免疫性 梅尼埃病 局部治疗 

分 类 号：R764[医药卫生—耳鼻咽喉科]