胸腺肽β4在心脏损伤修复中的作用研究进展  

Progress in the role of thymosin β4 in heart injury repair

作　　者：刘传斌[1] 吕双红[1] 张孝忠[1] 

机构地区：[1]解放军第307医院心血管内科,北京硕士研究生100071

出　　处：《中华临床医师杂志（电子版）》2014年第1期116-119,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：首都卫生发展科研专项基金(首发2011-5006-02);解放军第307医院创新科研基金

摘　　要：胸腺肽β4(Tβ4)是一种具有多种生物功能的肽,目前广泛应用于创伤修复和再生领域。近年的研究发现,Tβ4不仅与胚胎心血管发育相关,还在心脏损伤修复中具有心肌保护及促再生、促新生血管形成、抑制炎症反应、抑制心肌纤维化、增强干细胞移植治疗缺血性心脏病效果的作用。Tβ4在心脏损伤修复中展现出的巨大潜力已经引起了研究者的广泛关注,本文对近年来Tβ4在心脏损伤修复中的作用研究进展进行综述。Thymosinβ4 （Tβ4） is a peptide with a variety of biological functions, now widely used in the field of wound healing and regeneration. Recent studies have found that, Tβ4 is not only associated with the embryonic cardiovascular development, but also can protect cardiomyocytes, promote regeneration of myocardial cells, promote angiogenesis, inhibit inflammation, inhibit fibrosis of myocardial, and enhance the effect of stem cell transplantation in the treatment of ischemic heart disease in heart injury. Tβ4 shows the huge potential in injury repair has attracted wide attention of researchers, we reviewed recent studies of the role of Tβ4 in heart injury repair.

关 键 词：胸腺肽β4 心脏损伤 心肌再生 血管新生 

分 类 号：R541[医药卫生—心血管疾病]