中脑脚间区弥散加权成像信号与表观弥散系数的分析研究  

Evaluation of diffusion-weighted signal intensity and apparent diffusion coefficient in the interpeduncle region of midbrain

作　　者：马得廷[1] 王君霞[2] 孔庆奎[1] 谢元忠[1] 

机构地区：[1]山东省泰安市中心医院医学影像部,271000 [2]山东省泰安市中心医院产科,271000

出　　处：《中华临床医师杂志（电子版）》2014年第2期27-31,共5页Chinese Journal of Clinicians(Electronic Edition)

摘　　要：目的：探讨健康人群中脑脚间区弥散信号和表观弥散系数（ADC）值的特征及其与年龄、性别的相关性。方法回顾性分析216例健康人的横轴位DWI图像[TR/TE＝3200 ms/94 ms，4次信号采集，弥散敏感因子（b）值分别取0和1000 s/mm2，矩阵192×192，层厚5 mm，层距1.5 mm，视野＝230 mm]，其中男111例，女105例，年龄10～77岁，平均41.1岁。中脑脚间区与中脑导水管周围灰质的对比信噪比（CNR）和ADC值的比较采用配对样本t检验，性别之间指标的比较采用独立样本t检验。采用两变量直线相关分析中脑脚间区的CNR和ADC值与年龄的相关性。结果中脑脚间区信号明显高于中脑导水管周围灰质信号（CNR 25.48±7.25 vs.18.79±5.60；t＝20.465，P＝0.000）；男女性别间CNR无统计学差异（t＝-1.796，P＝0.074）。中脑脚间区CNR与年龄呈轻度正相关（r＝0.369，P＝0.000）。中脑脚间区的ADC值[（696.23±40.43）×10-6 mm2/s]明显低于中脑导水管周围灰质的 ADC 值[（741.28±44.92）×10-6 mm2/s]（t＝-14.654，P＝0.000）。男女性别间ADC值无统计学差异（t＝-1.199，P＝0.232）。中脑脚间区的ADC值与年龄没有相关性（r＝0.005， P＝0.936）。结论正常中脑脚间区在DWI图像中多呈高信号，其信号强度与年龄呈正相关而与性别无关，其ADC值与年龄、性别均没有相关性。DWI联合ADC有助于识别中脑脚间区的信号特征。Objective To evaluate the apparent diffusion coefficient （ADC） and signal intensity （SI） of the interpeduncle region （IPR） on diffusion-weighted imaging （DWI） and explore their relationships with age and gender in healthy subjects. Methods Brain axial diffusion-weighted images （spin-echo planar imaging sequence, TR/TE, 3 200/94 ms;diffusion gradient encoding in three orthogonal directions;b=0, 1 000 s/mm2;matrix, 192×192;section thickness, 5 mm;intersection gap,1.5 mm;and FOV, 230 mm） of 216 neurologically normal adults （111 men, 105 women; age range： 10-77 years, mean age： 41.1 years） were evaluated retrospectively. Contrast-to-noise ratios （CNR） and ADC value of the IPR and PAG were evaluated by two-paired samples t-test, respectively. Correlations between the CNR and ADC value in the IPR and age were statistically analyzed. Results The CNR was significantly higher in the IPR （25.48± 7.25） than in the PAG （18.79±5.60;t=20.465, P=0.000）. The CNRs tended to be lower in females than in males; however, this difference was not significant （t=-1.796, P=0.074）. The CNR of IPR was positively correlated with patients＆#39; age （r=0.369,P=0.000） by bivariate correlation. The ADC value was significantly lower in the IPR[（696.23 ± 40.43） × 10-6 mm2/s] than in the PAG[（741.28 ± 44.92） × 10-6 mm2/s];the difference was significant （t=-14.654, P=0.000）. The ADC values tended to be higher in males than in females;however, this difference was not significant （t=-1.199, P=0.232）. The ADC value of＆amp;nbsp;IPR was not correlate with age （r=0.005, P=0.936） by bivariate correlation. Conclusions The IPR usually shows high SI on DWI in healthy subjects. The SI of IPR significantly positively correlated with age but not with gender, and the ADC value of IPR shows no correlation with gender or age. DWI combined with the ADC maps would help to evaluate signal characteristics of the IPR.

关 键 词：中脑 信号处理 计算机辅助 磁共振成像 弥散 表观弥散系数 

分 类 号：R445.2[医药卫生—影像医学与核医学]