嗜肺军团菌主要毒力因子与细胞免疫反应  

Major virulence factors of legionella pneumophila and cell immune response

作　　者：严慧[1] 朱庆义[1] 

机构地区：[1]广州金域医学检验中心,510330

出　　处：《中华临床医师杂志（电子版）》2014年第2期146-149,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金面上项目(31270049);国家自然科学基金青年基金(31300004)

摘　　要：嗜肺军团菌是胞内的寄生菌,主要以细胞免疫为主,是引起社区获得性和医院内感染性肺炎的重要病原体,其致病性与毒力因子密切相关。Dot/IcmⅣ分泌系统是嗜肺军团菌的重要毒力因子,能诱发大量底物效应蛋白,激活免疫调控因子如NF-κB,调控嗜肺军团菌细胞内的生长繁殖。该细菌表面主要毒力因子如Mip蛋白、鞭毛蛋白和LPS脂多糖等,与嗜肺军团菌侵染和繁殖能力有关,在细胞免疫反应中具有重要作用。本文简要概述了嗜肺军团菌几个主要毒力因子、致病性以及与寄主免疫之间的相互关系。Legionella pneumophila （L. pneumophila） is an intracellular pathogen, it is a common cause of community-acquired respiratory tract infections and an occasional cause of nosocomial pneumonia. The pathogenicity is closely related to its virulence factors. The main protective role was played by the cellular responses after L. pneumophila infection. The Dot/IcmⅣ type secretion system is the main virulence factor of L. pneumophila, secretes a large number of effector proteins into infected cells. These effectors activate immune regulator factors like NF-κB, and mediated the L. pneumophila intracellular growth and replication. The other main virulence factors, such as Mip, flagellin and LPS, are referred to its infection and reproductive capacity, and play an important role in the cell immune response. This review will focus on the interactions between the major virulence factors of L. pneumophila and its pathogenicity, and discuss implications for the study of the immune detection mechanisms.

关 键 词：军团病杆菌 嗜肺 毒力因子类 先天免疫 Dot IcmⅣ分泌系统 

分 类 号：R378[医药卫生—病原生物学]