三氟乙酸乙酯和甲酯在有机合成中的应用进展  

Advances on the Applications of Ethyl and Methyl Trifluoroacetate in Organic Synthesis

作　　者：叶冬菊[1] 郑土才[1] 叶山海 王小青 

机构地区：[1]衢州学院化学与材料工程学院,324000 [2]浙江海昇化学有限公司,浙江衢州324004

出　　处：《化工生产与技术》2014年第1期13-19,70,共7页Chemical Production and Technology

基　　金：衢州市科技计划项目(20121019;20121040)

摘　　要：介绍了三氟乙酸乙酯和甲酯的制备,叙述了他们在有机合成中的应用进展,讨论了由其制备三氟乙酰乙酸乙酯及其应用,由其与酮经Claisen缩合制备β-二酮类化合物等。指出应加强对三氟乙酸乙酯和甲酯的工艺改进和工业化研究,特别是加强应用研究,充分发挥它们作为有机合成保护基和砌块的应用。This paper first reviewed the preparation of ethyl and methyl trifluoroacetate, then summarized recent researches on their applications in organic synthesis, with particular emphasis on the uses of its major derivative ethyl trifluoacetoacetate, and on their applications in Claisen condensation with ketones to prepare trifluoromethylated β-diones. Future studies should focus on the technology improvement and industrial research especially on the applications of ethyl and methyl trifluoro- acetate as important protecting groups and valuable building blocks.

关 键 词：三氟乙酸乙酯 三氟乙酰乙酸乙酯 杂环化合物 Claisen缩合 Β-二酮 合成 

分 类 号：TQ225.24[化学工程—有机化工]