三唑类化合物的合成及抑菌活性  

Synthesis of triazole compounds and evaluation of their antimicrobial activities

作　　者：燕乐乐[1] 刘幸平[1] 程康华[2] 李靖[1] 

机构地区：[1]南京中医药大学药学院,江苏南京210046 [2]南京林业大学化学工程学院,江苏南京210037

出　　处：《南京林业大学学报（自然科学版）》2014年第2期161-164,共4页Journal of Nanjing Forestry University：Natural Sciences Edition

基　　金：国家林业公益性行业科研专项项目(201104032)

摘　　要：为了获得高活性的木材防腐剂,以1,3-二氯苯为原料,依次经过傅克酰基化、烷基化、环氧化及开环反应得到6种三唑类化合物Y-4(a-f),且所有化合物的结构经过MS和1H-NMR确定;采用滤纸片法对常见的两种霉菌和两种木腐菌进行活性抑菌实验。结果表明:6种化合物中,Y-4d表现出的抗菌谱较广,对木材霉菌和腐朽菌都有抑制作用,但对腐朽菌的抑制效果不如Y-4c和Y-4f,Y-4c和Y-4f对木材腐朽菌表现出较强的抑制能力。In order to get a wood preservative with higher efficiency, six compounds Y-4（ a-f） were synthesized using 1, 3-dichlorobenzene as the starting material by Friedel-crafts acetylation, alkylation, epoxidation, and ring-opening re-action. The structures of these compounds were determined by MS and 1 H-NMR. Antifungal activities of these compounds were evaluated by two moulds and two decay fungi with Filter paper diffusion. The results indicated that Y-4d had a broad spectrum of antibacteria on moulds and decay fungi, but Y-4c and Y-4f had better antibacterial effect on decay fungi.

关 键 词：三唑类化合物 抑菌效果 木材防腐剂 

分 类 号：S482.2[农业科学—农药学]